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EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.

EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.
Posted by Seth

EOS plays an important role in maintaining the suppressive function of regulatory T cells (Treg), and a set of Tregs induced transformation into T helper-like cells, which are able to secrete proinflammatory cytokines in response to certain inflammatory signals. Meanwhile, a significant reduction in Treg activity along with the production of proinflammatory cytokines have been reported in patients with HTLV-1-associated myelopathy / tropical spastic paraparesis (HAM / TSP) .In this study, to test whether there is a change in the expression of EOS in mononuclear cells peripheral blood (PBMC) were from individuals HTLV-1-infected mainly HAM / TSP, we examined the expression of HTLV-1 genotype tax proviral load (PVL), and the mRNA expression of taxes, HBZ and EOS in HTLV- 1 infected individuals, including cell T adult leukemia / lymphoma (ATL), HAM / TSP, or asymptomatic carriers.

EOS expression levels of mRNA and protein in various HTLV-1-infected or uninfected human T cell line investigated.EOS also highly expressed at the protein level in most of HTLV-1 line-infected T cells, and added after the HTLV-1 Tax regulatory factors induced in the JPX-9 Tax-induced cell lines. Immunoprecipitation experiments showed physical interaction between EOS and Tax viral regulatory protein, but not HBZ. Meanwhile, there was a significant reduction in the level of mRNA in PBMCs EOS HTLV-1 infected individuals regardless of their clinical status.

We found an inverse correlation between the level of the EOS mRNA and HTLV-1 PVL in patients with ATL, and a positive correlation between the two load EOS mRNA and PVL, and EOS and load HBZ mRNA in patients with HAM / TSP, whereas this correlation was not observed in other clinical findings statuses .

These show that both Tax and HBZ can alter the expression of EOS through a mechanism that has not been determined, and dysregulation EOS expression in PBMCs HTLV-1 infected individuals may contribute to the pathological development of HTLV-1-related diseases, such as ATL and HAM / TSP.

 EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.
EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.

Downregulation of miR-4772-3p promote enhanced capacity of regulatory T cells in malignant pleural effusions by elevating the level of Helios.

malignant pleural effusion (MPE) is a complex condition of patients with advanced tumor. Further dissect immune cells infiltrate the microenvironment of malignant cells and are guaranteed to understand the immune-evasion mechanisms of tumor development and progression.

The possible involvement of microRNAs (miRNAs) in malignant pleural fluid were investigated using small RNA sequencing. regulatory T cells (Treg) markers (CD4, CD25, forkhead box P3) and Helios (also known as IKAROS Family Zinc Finger 2 [IKZF2]) were detected using flow cytometry. The expression level of miR-4772-3p IKZF2 and measured using real-time quantitative reverse transcription polymerase chain reaction. Interaction between miR-4772-3p and Helios determined using dual-luciferase reporter test.

Effects of miR-4772-3p on Helios expression was evaluated using in vitro system. test the correlation between miR-4772-3p and functional molecules Tregs that performed.Compared with non-malignant controls, patients with lung cancer non-small cell has an increased frequency of Tregs with MPE and Helios expression in peripheral blood mononuclear cells. the downregulation of miR-4772-3p verified inversely proportional to the frequency of Tregs Helios and Helios expression in the MPE. Overexpression of miR-4772-3p could inhibit the expression of Helios in vitro experiments.

beta Endorphin (bEP) Antibody

abx139815-100g 100 µg
EUR 275

beta Endorphin (bEP) Antibody

abx101064-100l 100 µl
EUR 250

beta Endorphin (bEP) Antibody

abx101064-1ml 1 ml
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beta Endorphin (bEP) Antibody

abx101064-200l 200 µl
EUR 312.5

Endorphin, beta (Rat) - Antibody

H-022-33 50 μl
EUR 238.68

Endorphin, beta (Human) - Antibody

H-022-14 50 μl
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beta Endorphin rabbit polyclonal antibody

20063 100 µl Ask for price

beta Endorphin rabbit polyclonal antibody

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Endorphin, beta (Rat) - Purified IgG Antibody

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Endorphin, beta (Human) - Purified IgG Antibody

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Endorphin, beta (Mouse, Bovine, Ovine, Camel) - Antibody

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Endorphin, beta (Rat)

022-33 200 μg
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beta Endorphin Peptide

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beta Endorphin Peptide

abx265065-1mg 1 mg
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beta Endorphin Peptide

abx265065-5mg 5 mg
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beta Endorphin Peptide

abx265471-100tests 100 tests
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beta Endorphin Peptide

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EUR 1025

beta Endorphin Peptide

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beta Endorphin Peptide

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beta Endorphin Peptide

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beta Endorphin Peptide

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beta Endorphin Peptide

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Endorphin, beta-neo

021-44 100 μg
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Endorphin, beta (Human)

022-14 200 μg
EUR 44.28

beta Endorphin (27-31) Peptide

20-abx265173
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beta Endorphin (30-31) Peptide

20-abx265174
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beta Endorphin (18-31) Peptide

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beta Endorphin (27-31) Peptide

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abx265174-1mg 1 mg
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beta Endorphin (18-31) Peptide

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Endorphin, beta (Equine)

022-09 200 μg
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Endorphin, beta (Porcine)

022-32 200 μg
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abx265157-5mg 5 mg
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beta Endorphin (1-27) Peptide

abx265158-10mg 10 mg
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beta Endorphin (1-27) Peptide

abx265158-1mg 1 mg
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beta Endorphin (1-27) Peptide

abx265158-5mg 5 mg
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beta Endorphin (1-27) Peptide

abx265437-100tests 100 tests
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beta Endorphin (1-27) Peptide

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beta Endorphin mouse monoclonal antibody, clone B31.15, Purified

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Ac beta Endorphin Peptide

abx265118-10mg 10 mg
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Ac beta Endorphin Peptide

abx265118-1mg 1 mg
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Ac beta Endorphin Peptide

abx265118-5mg 5 mg
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Ac beta Endorphin Peptide

abx265430-100tests 100 tests
EUR 675

Ac beta Endorphin Peptide

abx265430-200tests 200 tests
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Ac beta Endorphin Peptide

abx265430-50tests 50 tests
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Horse Beta Endorphin Peptide

abx266949-1ml 1 ml
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Horse Beta Endorphin Peptide

abx266949-200l 200 µl
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Endorphin, beta (18-31) (Human)

022-30 200 μg
EUR 50.76

Endorphin, beta (Human) - MagBead (Magnetic Bead Linked Antibody)

MB-022-14 1 ml
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Endorphin, beta (2-31) (Human)

022-15 200 μg
EUR 44.28

Endorphin, beta (1-26) (Human)

022-27 200 μg
EUR 86.4

Endorphin, beta (1-27) (Human)

022-28 200 μg
EUR 58.32

Endorphin, beta (6-31) (Human)

022-29 200 μg
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beta Endorphin (1-5), (16-31) Peptide

abx265249-10mg 10 mg
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beta Endorphin (1-5), (16-31) Peptide

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beta Endorphin (1-5), (16-31) Peptide

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Rat beta Endorphin ELISA kit

E02E0219-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat beta Endorphin ELISA kit

E02E0219-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat beta Endorphin ELISA kit

E02E0219-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog beta Endorphin ELISA kit

E08E0219-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog beta Endorphin ELISA kit

E08E0219-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog beta Endorphin ELISA kit

E08E0219-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig beta Endorphin ELISA kit

E07E0219-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig beta Endorphin ELISA kit

E07E0219-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig beta Endorphin ELISA kit

E07E0219-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Beta- Endorphin ELISA Kit

ELA-E0806r 96 Tests
EUR 1063.2

Goat beta Endorphin ELISA kit

E06E0219-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat beta Endorphin ELISA kit

E06E0219-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat beta Endorphin ELISA kit

E06E0219-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Beta- Endorphin ELISA Kit

ELA-E0806g 96 Tests
EUR 1113.6

Mouse beta Endorphin ELISA kit

E03E0219-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse beta Endorphin ELISA kit

E03E0219-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse beta Endorphin ELISA kit

E03E0219-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human beta Endorphin ELISA kit

E01E0219-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human beta Endorphin ELISA kit

E01E0219-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human beta Endorphin ELISA kit

E01E0219-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Endorphin, beta (Rat) - EIA Kit

EK-022-33 96 wells
EUR 603.72

Endorphin, beta (Rat) - RIA Kit

RK-022-33 125 tubes
EUR 932.04

Monkey beta Endorphin ELISA kit

E09E0219-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey beta Endorphin ELISA kit

E09E0219-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey beta Endorphin ELISA kit

E09E0219-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit beta Endorphin ELISA kit

E04E0219-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit beta Endorphin ELISA kit

E04E0219-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit beta Endorphin ELISA kit

E04E0219-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Beta- Endorphin ELISA Kit

ELA-E0806Rb 96 Tests
EUR 1113.6

alpha Neo Endorphin Antibody

GWB-B8B62B 0.05 ml Ask for price

Endorphin, beta (Human) - EIA Kit

EK-022-14 96 wells
EUR 603.72

Endorphin, beta (Human) - RIA Kit

RK-022-14 125 tubes
EUR 932.04

[Des-Tyr1] beta Endorphin Peptide

abx265213-10mg 10 mg
EUR 987.5

[Des-Tyr1] beta Endorphin Peptide

abx265213-1mg 1 mg
EUR 287.5

[Des-Tyr1] beta Endorphin Peptide

abx265213-5mg 5 mg
EUR 637.5

Cow beta Endorphin (bEP) CLIA Kit

20-abx490243
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  • 10 × 96 tests
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  • 96 tests

Cow beta Endorphin (bEP) ELISA Kit

20-abx150076
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Endorphin, beta (Porcine) - EIA Kit

EK-022-32 96 wells
EUR 603.72

Human Beta- endorphin, BEP ELISA KIT

ELI-02722h 96 Tests
EUR 988.8

Human beta Endorphin (bEP) ELISA Kit

20-abx150804
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  • 10 × 96 tests
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  • 96 tests

Guinea pig beta Endorphin ELISA kit

E05E0219-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig beta Endorphin ELISA kit

E05E0219-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig beta Endorphin ELISA kit

E05E0219-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig beta Endorphin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Canine Beta- endorphin, BEP ELISA KIT

ELI-02721d 96 Tests
EUR 1113.6

Rabbit beta Endorphin (bEP) ELISA Kit

abx585431-100g 100 µg
EUR 3212.5

Rabbit beta Endorphin (bEP) ELISA Kit

abx585431-1mg 1 mg
EUR 6075

Rabbit beta Endorphin (bEP) ELISA Kit

abx585431-50g 50 µg
EUR 675

Endorphin, beta (Rat) - Biotin Labeled

B-022-33 100 μg
EUR 336.96

Human beta Endorphin (bEP) Protein (OVA)

20-abx651108
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Human beta Endorphin (bEP) Peptide (OVA)

abx651108-5mg 5 mg
EUR 500

Endorphin, beta (Human) - Biotin Labeled

B-022-14 100 μg
EUR 336.96

Endorphin, beta (Rat) - I-125 Labeled

T-022-33 10 μCi
EUR 1145.88

Bovine beta endorphin(β-EP) ELISA Kit

QY-E60145 96T
EUR 511.2

Endorphin, beta (Human) - I-125 Labeled

T-022-14 10 μCi
EUR 1145.88

Endorphin, beta (1-27) (Bovine, Ovine, Camel)

022-08 200 μg
EUR 58.32

Endorphin, beta (Rat) - Fluorescent EIA Kit

FEK-022-33 96 wells
EUR 660.96

Endorphin, beta (Mouse, Bovine, Ovine, Camel)

022-06 200 μg
EUR 58.32

Endorphin, beta (Human) - Fluorescent EIA Kit

FEK-022-14 96 wells
EUR 660.96

Endorphin, beta (Porcine) - Fluorescent EIA Kit

FEK-022-32 96 wells
EUR 660.96

Endorphin, beta (Human) - Magnetic Bead RIA Kit

MRK-022-14 125 tubes
EUR 1061.64

Endorphin, alpha-Neo (Porcine) - Antibody

H-021-40 50 μl
EUR 238.68

Endorphin, beta (Human) - EIA Kit, CE Mark Certified

EK-022-14CE 96 wells
EUR 629.64

Endorphin, beta (Mouse, Bovine, Ovine, Camel) - EIA Kit

EK-022-06 96 wells
EUR 603.72

Endorphin, beta (Mouse, Bovine, Ovine, Camel) - RIA Kit

RK-022-06 125 tubes
EUR 932.04

Endorphin, beta (Rat) - I-125 Labeled Purified IgG

T-G-022-33 10 μCi
EUR 1145.88

Endorphin, beta (Human) - I-125 Labeled Purified IgG

T-G-022-14 10 μCi
EUR 1145.88

Human α-Endorphin(alpha Endorphin) ELISA Kit

EKF59099-48T 48T
EUR 396.9

Human α-Endorphin(alpha Endorphin) ELISA Kit

EKF59099-5x96T 5x96T
EUR 2693.25

Human α-Endorphin(alpha Endorphin) ELISA Kit

EKF59099-96T 96T
EUR 567

Human α-Endorphin(alpha Endorphin) ELISA Kit

EH4308 96T
EUR 628.92
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

[Di-Biotinyl-Lys]-Endorphin, beta (Human) - Biotin Labeled

B-022-16 100 μg
EUR 336.96

Endorphin, gamma / Lipotropin, beta (61-77) (Human, Bovine, Ovine, Camel)

022-36 500 μg
EUR 81

Endorphin, alpha-Neo (Porcine) - Purified IgG Antibody

G-021-40 400 μg
EUR 438.48

Endorphin, beta (Human) - Fluorescent EIA Kit, CE Mark Certified

FEK-022-14CE 96 wells
EUR 686.88

δ–Endorphin

5-00511 4 x 5mg Ask for price

Endorphin, beta (Mouse, Bovine, Ovine, Camel) - Fluorescent EIA Kit

FEK-022-06 96 wells
EUR 660.96

α-Endorphin

4009491.0001 1 mg
EUR 112.35

α-Endorphin

4009491.0005 5 mg
EUR 449.4

Ac-beta- Endorphin, bovine, camel, ovine

5-00541 4 x 1mg Ask for price

β-Endorphin (rat)

4030577.05 0.5 mg
EUR 102.27

β-Endorphin (rat)

4030577.1 1 mg
EUR 168.53

β-Endorphin (rat)

T35460-10mg 10mg Ask for price
Description: β-Endorphin (rat)

β-Endorphin (rat)

T35460-1g 1g Ask for price
Description: β-Endorphin (rat)

β-Endorphin (rat)

T35460-1mg 1mg Ask for price
Description: β-Endorphin (rat)

β-Endorphin (rat)

T35460-50mg 50mg Ask for price
Description: β-Endorphin (rat)

β-Endorphin (rat)

T35460-5mg 5mg Ask for price
Description: β-Endorphin (rat)

β-Endorphin (30-31) (human)

4002438.0005 5 g
EUR 102.27

β-Endorphin (30-31) (human)

4002438.0025 25 g
EUR 412.34

[Des-Tyr1]-Endorphin, gamma / Lipotropin, beta (62-77) (Human, Bovine, Ovine, Camel)

022-38 500 μg
EUR 81

β-Endorphin (human)

4006426.0001 1 mg
EUR 149.42

β-Endorphin (human)

4006426.0005 5 mg
EUR 598.82

β-Endorphin, human

HY-P1502 1mg
EUR 253.2

β-Endorphin, human

T13433-10mg 10mg Ask for price
Description: β-Endorphin, human

β-Endorphin, human

T13433-1g 1g Ask for price
Description: β-Endorphin, human

β-Endorphin, human

T13433-1mg 1mg Ask for price
Description: β-Endorphin, human

β-Endorphin, human

T13433-50mg 50mg Ask for price
Description: β-Endorphin, human

β-Endorphin, human

T13433-5mg 5mg Ask for price
Description: β-Endorphin, human

β-Endorphin, equine

TP1647-10mg 10mg Ask for price
Description: β-Endorphin, equine

β-Endorphin, equine

TP1647-1g 1g Ask for price
Description: β-Endorphin, equine

β-Endorphin, equine

TP1647-1mg 1mg Ask for price
Description: β-Endorphin, equine

β-Endorphin, equine

TP1647-50mg 50mg Ask for price
Description: β-Endorphin, equine

β-Endorphin, equine

TP1647-5mg 5mg Ask for price
Description: β-Endorphin, equine

β-Endorphin (6-31) (human)

4030554.0001 1 mg
EUR 149.42

β-Endorphin (6-31) (human)

4030554.0005 5 mg
EUR 598.82

delta Endorphin Peptide

20-abx266510
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delta Endorphin Peptide

abx266510-1ml 1 ml
EUR 612.5

However, ectopic expression of Helios, induced Tregs reversed the effects caused by excessive mir-4772-3p. In addition, miR-4772-3p can regulate the expression of Helios by directly targeting IKZF2 mRNA.Downregulation of miR-4772-3p, by targeting Helios, contributing to the activities of Tregs increased in the microenvironment of MPE.

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