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Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma.

Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma.
Posted by Seth

Epstein-Barr virus (EBV) establishes a lifelong latent infection in humans and is associated with several lymphoid and epithelial cancers. In nasopharyngeal carcinoma (NPC), EBV revealed several viral proteins but increased levels of Bam-HI A right to the transcript (Barts) RNA, including viral microRNAs and long non-coding RNA (lncRNAs). BART lncRNAs localize in the nucleus of EBV-infected cells and knockdown of BART lncRNAs significantly affect the expression of genes associated with cell adhesion, oxidoreductase activity, inflammation, and immunity.

Specifically, downregulation of IKAROS zinc finger family of 3 (IKZF3 / Aeolus), which plays a role in lymphocyte development and attachment of cells, occurs in cells following C666-1 NPC lncRNA BART-knockdown. Since the expression of Aeolus is usually limited to cells of lymphoid and rarely observed in the epithelial cells, induction of Aeolus by lncRNA BART BART confirmed by major express lncRNA isoforms, RPMS1, in EBV-positive cells and negative.

BART lncRNA associated with CBP / p300 complex and RNA polymerase II (Pol II) in the nucleus, suggesting that the BART lncRNAs can mediate epigenetic regulation of gene expression through interactions with chromatin remodeling machinery. This assumption is further supported by evidence that the BART lncRNA seemed to stall Pol II promoter region and can arrange IFNB1 and CXCL8 expression by inhibiting transcription by Pol II at the NPC.

We hypothesize that EBV BART lncRNA modulated expression host gene expression and sustain EBV latency by interrupting the process of histone methylation and acetylation. aberrant expression of genes affected host mediated by BART lncRNA can cause immune evasion, growth, and metastasis of NPC.

Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma.
Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma.

[The effect of increasing the intensity of chemotherapy on the prognosis of acute lymphoblastic leukemia in children with IKZF1 deletion].

To study the clinical features of acute lymphoblastic leukemia (ALL) in children with IKAROS family of zinc finger 1 (IKZF1) deletion, and to observe the effect of increasing the intensity of chemotherapy in this prognosis disease.A number of 278 children diagnosed with ALL between December 2015 and February 2018 were systematically treated in accordance with the 2008-ALL Leukemia Group protocol Chinese Children (CCLG-ALL 2008).

The patients were divided into groups IKZF1-cleared and control groups according to the presence or absence of IKZF1. IKZF1-erased group treated with the regimen for high-risk groups (SDM) in CCLG-ALL protocol of 2008, while the control group receiving different intensities of chemotherapy according to clinical risk classification. Clinical features and rate of event-free survival (EFS) compared between the two groups.


RESULTS
A total of 24 (8.6%) cases of 278 children were found to have a large deletion of exon gene IKZF1. IKZF1-deleted group have significantly higher proportion of cases with white blood cell counting ≥50 × 109 / L at initial diagnosis, BCR-ABL1 fusion gene positive, minimal residual disease ≥10% on the 15th of remission induction treatment, minimal residual disease- high-risk and high-risk clinical risk classification compared with the control group (P <0.05).

Tachykinin Receptor 3 (TACR3) Antibody

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EUR 237.5

Tachykinin Receptor 3 (TACR3) Antibody

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Tachykinin Receptor 3 (TACR3) Antibody

abx006440-100g 100 µg
EUR 275

Tachykinin Receptor 3 (TACR3) Antibody

20-abx006440
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Tachykinin Receptor 3 (TACR3) Antibody

abx006440-10g 10 µg
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Tachykinin Receptor 3 (TACR3) Antibody

abx006440-200g 200 µg
EUR 400

Tachykinin Receptor 3 (TACR3) Antibody

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EUR 518.75

Tachykinin Receptor 3 (TACR3) Antibody

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EUR 627.6

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EUR 687.5

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Description: Rat

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EUR 562.5

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EUR 687.5

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EUR 662.5

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KLR2355 1 x 96 wells
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EUR 265

Human TACR3 (Tachykinin Receptor 3) ELISA Kit

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EUR 450

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EUR 2265

Human TACR3 (Tachykinin Receptor 3) ELISA Kit

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EUR 535

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EUR 125.55

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RE2151H-48wellsplate 48 wells plate
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EUR 179.55

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EUR 280

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EUR 495

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EUR 585

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EUR 495

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Rabbit TACR3 (Tachykinin Receptor 3) ELISA Kit

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EUR 585

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EUR 280

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EUR 495

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EUR 585

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EUR 495

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Tacr3 (Myc-DDK-tagged ORF) - Rat tachykinin receptor 3 (Tacr3), (10 ug)

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E-EL-H1963 1 plate of 96 wells
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Description: A sandwich ELISA kit for quantitative measurement of Human TACR3 (Tachykinin Receptor 3) in samples from Serum, Plasma, Cell supernatant

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Description: 0.1 ng/mL

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Tachykinin Receptor 2 (TACR2) Antibody

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abx328174-50g 50 µg
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abx324327-50g 50 µg
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Tachykinin Receptor 2 (TACR2) Antibody

abx007341-10g 10 µg
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Tachykinin Receptor 2 (TACR2) Antibody

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Tachykinin Receptor 1 (TACR1) Antibody

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Tachykinin Receptor 1 (TACR1) Antibody

abx015349-1mg 1 mg
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Tachykinin Receptor 1 (TACR1) Antibody

20-abx178530
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Tachykinin Receptor 2 (TACR2) Antibody

20-abx178531
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Tachykinin Receptor 2 (TACR2) Antibody

abx211186-100l 100 µl
EUR 350

Tachykinin Receptor 2 (TACR2) Antibody

20-abx211186
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Tachykinin Receptor 2 (TACR2) Antibody

abx211186-50l 50 µl
EUR 250

Tachykinin Receptor 2 (TACR2) Antibody

abx130253-100l 100 µl
EUR 262.5

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Tachykinin Receptor 2 (TACR2) Antibody

abx130253-1ml 1 ml
EUR 725

Tachykinin Receptor 2 (TACR2) Antibody

abx130253-200l 200 µl
EUR 337.5

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20-abx102297
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Tachykinin Receptor 2 (TACR2) Antibody

abx102297-1ml 1 ml
EUR 675

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abx102297-200l 200 µl
EUR 312.5

Tachykinin Receptor 1 (TACR1) Antibody

abx115974-100g 100 µg Ask for price

Tachykinin Receptor 1 (TACR1) Antibody

abx115974-10g 10 µg
EUR 612.5

Tachykinin Receptor 1 (TACR1) Antibody

20-abx115974
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Tachykinin Receptor 1 (TACR1) Antibody

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Tachykinin Receptor 1 (TACR1) Antibody

20-abx121769
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Tachykinin Receptor 1 (TACR1) Antibody

abx110235-100l 100 µl
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Tachykinin Receptor 1 (TACR1) Antibody

20-abx110235
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Tachykinin Receptor 2 (TACR2) Antibody

abx238471-100g 100 µg
EUR 350

Tachykinin Receptor 2 (TACR2) Antibody

abx238471-100ug 100 ug
EUR 661.2

Anti- Tachykinin Receptor 2 (TACR2) Human Antibody

GWB-D5770F 0.05 mg Ask for price

Anti- Tachykinin Receptor 2 (TACR2) Human Antibody

GWB-C83E99 0.05 mg Ask for price

Lenti ORF clone of Tacr3 (Myc-DDK-tagged) - Mouse tachykinin receptor 3 (Tacr3)

MR207221L3 10 µg Ask for price

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3)

MBS6006043-02mL 0.2(mL
EUR 695

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3)

MBS6006043-5x02mL 5x0.2mL
EUR 2975

Tachykinin Receptor 1 (TACR1) Antibody Pair

abx117530-1pair5x96wellplates 1 pair (5x96 well plates)
EUR 1212

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (AP)

MBS6353270-02mL 0.2mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (AP)

MBS6353270-5x02mL 5x0.2mL
EUR 4250

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (APC)

MBS6353271-02mL 0.2mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (APC)

MBS6353271-5x02mL 5x0.2mL
EUR 4250

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MBS6353273-02mL 0.2mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (FITC)

MBS6353273-5x02mL 5x0.2mL
EUR 4250

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (PE)

MBS6353280-02mL 0.2mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (PE)

MBS6353280-5x02mL 5x0.2mL
EUR 4250

Lenti ORF clone of Tacr3 (mGFP-tagged ORF) - Rat tachykinin receptor 3 (Tacr3), (10 ug)

RR206329L4 10 µg Ask for price

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (Biotin)

MBS6353272-02mL 0.2mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (Biotin)

MBS6353272-5x02mL 5x0.2mL
EUR 4250

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (MaxLight 405)

MBS6353275-01mL 0.1mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (MaxLight 405)

MBS6353275-5x01mL 5x0.1mL
EUR 4250

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (MaxLight 490)

MBS6353276-01mL 0.1mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (MaxLight 490)

MBS6353276-5x01mL 5x0.1mL
EUR 4250

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (MaxLight 550)

MBS6353277-01mL 0.1mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (MaxLight 550)

MBS6353277-5x01mL 5x0.1mL
EUR 4250

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (MaxLight 650)

MBS6353278-01mL 0.1mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (MaxLight 650)

MBS6353278-5x01mL 5x0.1mL
EUR 4250

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (MaxLight 750)

MBS6353279-01mL 0.1mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (MaxLight 750)

MBS6353279-5x01mL 5x0.1mL
EUR 4250

Lenti ORF clone of Tacr3 (Myc-DDK-tagged ORF) - Rat tachykinin receptor 3 (Tacr3), (10 ug)

RR206329L3 10 µg Ask for price

Lenti ORF particles, Tacr3 (GFP-tagged) - Mouse tachykinin receptor 3 (Tacr3), 200ul, >10^7 TU/mL

MR207221L4V 200 µl Ask for price

Lenti ORF clone of Human tachykinin receptor 3 (TACR3), mGFP tagged

RC211425L2 10 µg Ask for price

Lenti ORF clone of Human tachykinin receptor 3 (TACR3), mGFP tagged

RC211425L4 10 µg Ask for price

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (Azide free) (HRP)

MBS6353274-02mL 0.2mL
EUR 980

TACR3, CT (TACR3, NK3R, TAC3R, Neuromedin-K receptor, NK-3 receptor, Neurokinin B receptor, Tachykinin receptor 3) (Azide free) (HRP)

MBS6353274-5x02mL 5x0.2mL
EUR 4250

Tachykinin Receptor 1 (TACR1) Polyclonal Antibody

CAU31051-100ul 100ul
EUR 212.2

Tachykinin Receptor 1 (TACR1) Polyclonal Antibody

CAU31051-200ul 200ul
EUR 265.4

Tachykinin Receptor 2 (TACR2) Polyclonal Antibody

CAU27516-100ul 100ul
EUR 229.4

Tachykinin Receptor 2 (TACR2) Polyclonal Antibody

CAU27516-200ul 200ul
EUR 287.3

3-year EFS rates (76% ± 10%) in the group-deleted IKZF1 lower than in the control group (84% ± 4%), but with no significant difference between the two groups (P = 0.282). An estimated 3 year rate of EFS in a group IKZF1-cleared non-HR (actually treated with chemotherapy regimens for HR in CCLG-ALL protocol 2008) was 82% ± 12%, lower than that in the control-which is a group of non-HR (86 % ± 5%), but no significant difference (P = 0.436).

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An investigation of methylation pattern changes in the IKZF1 promoter in patients with childhood B-cell acute lymphoblastic leukemia.

An investigation of methylation pattern changes in the IKZF1 promoter in patients with childhood B-cell acute lymphoblastic leukemia.
Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits, Uncategorized, Vector & Virus, Western Blot

EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.

EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.

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