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Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma.

Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma.
Posted by Seth

Epstein-Barr virus (EBV) establishes a lifelong latent infection in humans and is associated with several lymphoid and epithelial cancers. In nasopharyngeal carcinoma (NPC), EBV revealed several viral proteins but increased levels of Bam-HI A right to the transcript (Barts) RNA, including viral microRNAs and long non-coding RNA (lncRNAs). BART lncRNAs localize in the nucleus of EBV-infected cells and knockdown of BART lncRNAs significantly affect the expression of genes associated with cell adhesion, oxidoreductase activity, inflammation, and immunity.

Specifically, downregulation of IKAROS zinc finger family of 3 (IKZF3 / Aeolus), which plays a role in lymphocyte development and attachment of cells, occurs in cells following C666-1 NPC lncRNA BART-knockdown. Since the expression of Aeolus is usually limited to cells of lymphoid and rarely observed in the epithelial cells, induction of Aeolus by lncRNA BART BART confirmed by major express lncRNA isoforms, RPMS1, in EBV-positive cells and negative.

BART lncRNA associated with CBP / p300 complex and RNA polymerase II (Pol II) in the nucleus, suggesting that the BART lncRNAs can mediate epigenetic regulation of gene expression through interactions with chromatin remodeling machinery. This assumption is further supported by evidence that the BART lncRNA seemed to stall Pol II promoter region and can arrange IFNB1 and CXCL8 expression by inhibiting transcription by Pol II at the NPC.

We hypothesize that EBV BART lncRNA modulated expression host gene expression and sustain EBV latency by interrupting the process of histone methylation and acetylation. aberrant expression of genes affected host mediated by BART lncRNA can cause immune evasion, growth, and metastasis of NPC.

Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma.
Epstein-Barr Virus BART Long Non-coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma.

[The effect of increasing the intensity of chemotherapy on the prognosis of acute lymphoblastic leukemia in children with IKZF1 deletion].

To study the clinical features of acute lymphoblastic leukemia (ALL) in children with IKAROS family of zinc finger 1 (IKZF1) deletion, and to observe the effect of increasing the intensity of chemotherapy in this prognosis disease.A number of 278 children diagnosed with ALL between December 2015 and February 2018 were systematically treated in accordance with the 2008-ALL Leukemia Group protocol Chinese Children (CCLG-ALL 2008).

The patients were divided into groups IKZF1-cleared and control groups according to the presence or absence of IKZF1. IKZF1-erased group treated with the regimen for high-risk groups (SDM) in CCLG-ALL protocol of 2008, while the control group receiving different intensities of chemotherapy according to clinical risk classification. Clinical features and rate of event-free survival (EFS) compared between the two groups.


RESULTS
A total of 24 (8.6%) cases of 278 children were found to have a large deletion of exon gene IKZF1. IKZF1-deleted group have significantly higher proportion of cases with white blood cell counting ≥50 × 109 / L at initial diagnosis, BCR-ABL1 fusion gene positive, minimal residual disease ≥10% on the 15th of remission induction treatment, minimal residual disease- high-risk and high-risk clinical risk classification compared with the control group (P <0.05).

Tachykinin Receptor 3 (TACR3) Antibody

abx027890-80l 80 µl
EUR 286

Tachykinin Receptor 3 (TACR3) Antibody

abx411977-01mg 0.1 mg
EUR 509

Tachykinin Receptor 3 (TACR3) Antibody

20-abx320070
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul

Tachykinin Receptor 3 (TACR3) Antibody

abx238472-100ug 100 ug
EUR 551

Human Tachykinin Receptor 3(TACR3)ELISA Kit

QY-E01371 96T
EUR 361

ELISA kit for Human TACR3 (Tachykinin Receptor 3)

E-EL-H1963 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human TACR3 (Tachykinin Receptor 3) in samples from Serum, Plasma, Cell supernatant

Tachykinin Receptor 3 Antibody

20-abx141264
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

Anti-TACR3 antibody

STJ29300 100 µl
EUR 277
Description: This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.

anti- TACR3 antibody

FNab08472 100µg
EUR 585
Description: Antibody raised against TACR3

Anti-TACR3 antibody

PAab08472 100 ug
EUR 412

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Anti-VEGF Receptor 3/FLT4 Antibody

A01276-3 100ug/vial
EUR 334

Neuromedin-K receptor (TACR3) Antibody

20-abx328066
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Tachykinin Receptor 3 Blocking Peptide

20-abx061962
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Tachykinin 3 antibody

70R-5340 50 ug
EUR 467
Description: Rabbit polyclonal Tachykinin 3 antibody

Anti-uPA Receptor/PLAUR Antibody

A00993-3 100ug/vial
EUR 334

Anti-Endothelin A Receptor Antibody

A01828-3 250ug
EUR 484
Description: Sheep Polyclonal Endothelin A Receptor Antibody. Validated in IHC and tested in Human, Mouse, Rat.

TACR3 Antibody

1-CSB-PA023070ESR2HU
  • EUR 222.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TACR3. Recognizes TACR3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

TACR3 Antibody

1-CSB-PA003454
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TACR3. Recognizes TACR3 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/10000

TACR3 Antibody

46680-100ul 100ul
EUR 252

Anti-Prolactin Receptor Monoclonal Antibody (U5)

M01196-3 100ug
EUR 765
Description: Mouse Monoclonal Prolactin Receptor Antibody (U5). Validated in IP, IF, IHC and tested in Human, Rat.

Anti-Aryl hydrocarbon Receptor/Ahr Antibody

A00225-3 100ug/vial
EUR 294

Anti-TNF Receptor I/TNFRSF1A Antibody

A00294-3 100ug/vial
EUR 334

Anti-VEGF Receptor 2/Kdr Antibody

A00901-3 100ug/vial
EUR 334

Tachykinin Receptor 2 (TACR2) Antibody

20-abx130253
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
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  • 100 ug
  • 10 ug
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Tachykinin Receptor 1 (TACR1) Antibody

20-abx121769
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Tachykinin Receptor 1 (TACR1) Antibody

20-abx115974
  • EUR 732.00
  • EUR 398.00
  • 150 ul
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Tachykinin Receptor 1 Antibody (Biotin)

20-abx105944
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
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Tachykinin Receptor 1 Antibody (FITC)

20-abx107359
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  • EUR 1845.00
  • EUR 599.00
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  • 100 ug
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Tachykinin Receptor 1 Antibody (HRP)

20-abx108780
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
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  • 200 ug
  • 20 ug
  • 50 ug

Tachykinin Receptor 1 (TACR1) Antibody

20-abx110235
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
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Tachykinin Receptor 2 (TACR2) Antibody

20-abx102297
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  • EUR 133.00
  • EUR 1107.00
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  • 100 ug
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Tachykinin Receptor 2 (TACR2) Antibody

20-abx007341
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  • 100 ul
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  • 20 ul
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Tachykinin Receptor 1 (TACR1) Antibody

20-abx004264
  • EUR 411.00
  • EUR 592.00
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  • 100 ul
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Tachykinin Receptor 1 (TACR1) Antibody

20-abx015349
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Tachykinin Receptor 2 (TACR2) Antibody

abx430612-200ul 200 ul
EUR 286

Tachykinin Receptor 1 (TACR1) Antibody

abx431635-200ul 200 ul
EUR 384

Tachykinin Receptor 2 (TACR2) Antibody

20-abx339430
  • EUR 411.00
  • EUR 300.00
  • 100 ul
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Tachykinin Receptor 2 (TACR2) Antibody

abx238471-100ug 100 ug
EUR 551

Tachykinin Receptor 1 (TACR1) Antibody

20-abx178530
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Tachykinin Receptor 2 (TACR2) Antibody

20-abx178531
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Tachykinin Receptor 1 (TACR1) Antibody

20-abx174707
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Tachykinin Receptor 2 (TACR2) Antibody

20-abx174708
  • EUR 787.00
  • EUR 411.00
  • 1 mg
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Tachykinin Receptor 2 (TACR2) Antibody

20-abx211186
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Tachykinin Receptor 1 (TACR1) Antibody

20-abx328174
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Tachykinin Receptor 2 (TACR2) Antibody

20-abx324327
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Pig Tachykinin Receptor 3 ELISA kit

E07T0076-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Tachykinin Receptor 3 ELISA kit

E07T0076-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Tachykinin Receptor 3 ELISA kit

E07T0076-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Tachykinin Receptor 3 ELISA kit

E08T0076-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Tachykinin Receptor 3 ELISA kit

E08T0076-48 1 plate of 48 wells
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Description: A competitive ELISA for quantitative measurement of Canine Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Tachykinin Receptor 3 ELISA kit

E08T0076-96 1 plate of 96 wells
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Description: A competitive ELISA for quantitative measurement of Canine Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tachykinin Receptor 3 ELISA kit

E04T0076-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tachykinin Receptor 3 ELISA kit

E04T0076-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Tachykinin Receptor 3 ELISA kit

E04T0076-96 1 plate of 96 wells
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Description: A competitive ELISA for quantitative measurement of Rabbit Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Tachykinin Receptor 3 ELISA kit

E06T0076-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Tachykinin Receptor 3 ELISA kit

E06T0076-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Tachykinin Receptor 3 ELISA kit

E06T0076-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Tachykinin Receptor 3 ELISA kit

E01T0076-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Tachykinin Receptor 3 ELISA kit

E01T0076-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Tachykinin Receptor 3 ELISA kit

E01T0076-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Tachykinin Receptor 3 ELISA kit

E03T0076-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Tachykinin Receptor 3 ELISA kit

E03T0076-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Tachykinin Receptor 3 ELISA kit

E03T0076-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Tachykinin Receptor 3 ELISA kit

E02T0076-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Tachykinin Receptor 3 ELISA kit

E02T0076-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Tachykinin Receptor 3 ELISA kit

E02T0076-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Tachykinin Receptor 3 ELISA kit

E09T0076-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Tachykinin Receptor 3 ELISA kit

E09T0076-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Tachykinin Receptor 3 ELISA kit

E09T0076-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Tachykinin-3 (TAC3) Antibody

20-abx004825
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Tachykinin-3 (TAC3) Antibody

abx028000-400ul 400 ul
EUR 523

Tachykinin-3 (TAC3) Antibody

abx028000-80l 80 µl
EUR 286

Anti-EGF Receptor Rabbit Monoclonal Antibody, Clone#RM294

M00023-3 100uL
EUR 427
Description: Anti-EGF Receptor Rabbit Monoclonal Antibody, Clone#RM294 tested in WB, IHC, reactive to Human

Anti-Phospho-NMDA Receptor NR2B Subunit (Tyr1472) Antibody

P01883-3 100ul
EUR 398
Description: Rabbit Polyclonal Phospho-NMDA Receptor NR2B Subunit (Tyr1472) Antibody. Validated in WB and tested in Mouse, Rat.

Tachykinin Receptor 1 (TACR1) Antibody Pair

abx117530-1pair5x96wellplates 1 pair (5x96 well plates)
EUR 1010

Tacr3/ Rat Tacr3 ELISA Kit

ELI-38281r 96 Tests
EUR 886

TACR3 Polyclonal Antibody

42339-100ul 100ul
EUR 333

TACR3 Conjugated Antibody

C46680 100ul
EUR 397

Guinea pig Tachykinin Receptor 3 ELISA kit

E05T0076-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Guinea pig Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Tachykinin Receptor 3 ELISA kit

E05T0076-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Guinea pig Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Tachykinin Receptor 3 ELISA kit

E05T0076-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Tachykinin Receptor 3 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-PR (Progesterone Receptor) Rabbit Monoclonal Antibody, Clone#RM357

M00541-3 100uL
EUR 385
Description: Anti-PR (Progesterone Receptor) Rabbit Monoclonal Antibody, Clone#RM357 tested in WB, IHC, reactive to Human

Anti-Androgen Receptor (AR-V7 specific) Rabbit Monoclonal Antibody

M00542-3 100ug/vial
EUR 397
Description: Rabbit Monoclonal Androgen Receptor (AR-V7 specific) Antibody. Validated in IHC, WB and tested in Human.

Tachykinin Receptor 1 Blocking Peptide

20-abx161479
  • EUR 606.00
  • EUR 1428.00
  • 1 mg
  • 5 mg

Recombinant Tachykinin Receptor 2 (TACR2)

4-RPA618Hu01
  • EUR 560.54
  • EUR 253.00
  • EUR 1827.04
  • EUR 675.68
  • EUR 1251.36
  • EUR 438.00
  • EUR 4417.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Tachykinin Receptor 2 expressed in: E.coli

Recombinant Tachykinin Receptor 2 (TACR2)

4-RPA618Ra01
  • EUR 530.08
  • EUR 245.00
  • EUR 1712.80
  • EUR 637.60
  • EUR 1175.20
  • EUR 418.00
  • EUR 4132.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Tachykinin Receptor 2 expressed in: E.coli

Anti-14-3-3 alpha + beta Rabbit Monoclonal Antibody

M02431-3 100ug/vial
EUR 397
Description: Rabbit Monoclonal 14-3-3 alpha + beta Antibody. Validated in Flow Cytometry, IP, IF, IHC, ICC, WB and tested in Human, Mouse, Rat.

Anti-active Caspase-3 Rabbit Monoclonal Antibody

M00334-3 100ug/vial
EUR 397
Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human

Anti-Galectin 3/LGALS3 Antibody (monoclonal, 12B12)

M00621-3 100ug/vial
EUR 334

TACR3 siRNA

20-abx935941
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

TACR3 siRNA

20-abx935942
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

TACR3 siRNA

20-abx905436
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
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Anti-Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Monoclonal Antibody

M00227-3 100ul
EUR 397
Description: Mouse Monoclonal Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Antibody. Validated in IHC, WB and tested in Equine.

Recombinant Human Tachykinin-3

7-06604 5µg Ask for price

Recombinant Human Tachykinin-3

7-06605 25µg Ask for price

Recombinant Human Tachykinin-3

7-06606 1mg Ask for price

3-year EFS rates (76% ± 10%) in the group-deleted IKZF1 lower than in the control group (84% ± 4%), but with no significant difference between the two groups (P = 0.282). An estimated 3 year rate of EFS in a group IKZF1-cleared non-HR (actually treated with chemotherapy regimens for HR in CCLG-ALL protocol 2008) was 82% ± 12%, lower than that in the control-which is a group of non-HR (86 % ± 5%), but no significant difference (P = 0.436).

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