Sensitive detection of recurrent colorectal cancer (CRC) by measuring circulating tumor DNA (ctDNA) can increase the chance of a cure. This study compared the quantitative methylated ctDNA test with carcinoembryonic antigen (CEA) in the supervision arrangements for recurrence.Blood samples collected either for surveillance or within 12 months of confirmation of recurrence was tested for ctDNA (methylated branched-chain amino acid transaminase 1 [BCAT1] / Ikaros 1 family of zinc-finger proteins [IKZF1]) and CEA.
CtDNA optimal threshold is determined by receiver operating characteristic analysis, and performance tests for the detection of recurrence compared with CEA (5 threshold ng / mL) .the study cohort comprised 144 patients were eligible and including 50 recurrence events.
Sensitivity tests ctDNA are methylated to recurrence was 66.0% (95% confidence interval [CI], 57.1% -69.3%), which was significantly higher than the sensitivity of CEA (31.9%; 95% CI, 22.8% -36.6%; P <0.001). Sensitivity for inoperable recurrence (n = 20) was also higher (ctDNA, 60.0%; CEA, 20.0%; P = 0.01). specificity did not differ between tests (ctDNA, 97.9%; 95% CI, 93.2% -99.6%; CEA, 96.4%; 95% CI, 91.4% -99.0%).
When adjusting for other predictors of the presence of recurrence, ctDNA tests positive is an independent predictor (odds ratio, 155.7; 95% CI, 17.9 to 1360.6; P <0.001), whereas CEA did not (odds ratio, 2, 5; 95% CI, 0.3 to 20.6; P = .407) .the quantitative ctDNA test indicate superior sensitivity as compared with CEA without differences in specificity for detecting recurrent CRC. Longitudinal studies are guaranteed to further assess the utility (especially the survival benefit) of alcohol BCAT1 / IKZF1 ctDNA in surveillance of patients with CRC.
Circulating epigenetic biomarkers for detection of recurrent colorectal cancer.
BRD4-Molecular Targets Set in Mantle Cell Lymphoma: Therapy Approach Target Insights.
Since bromodomain-containing protein 4 (BRD4) facilitating transcription of genes important for cell-cell specific neoplastic cancer types, BRD4-regulated molecule can also include a therapeutic target for mantle cell lymphoma (MCL), treatment-resistant subtype wildfire lymphoma.
In to the target BRD4-arranged directly reveal in MCL, we carried out with an integrated analysis by using the database and track the results of both the gene expression profile and chromatin immunoprecipitation with parallel sequencing to BRD4.Treatment with BRD4 inhibitor I-BET151 dose -dependent inhibitory effect on cell proliferation MCL cell lines. BRD4 found immediately arranged a series of genes involved in cell receptor B (BCR) signaling pathway, including linker-B cells (blnk), paired box 5 (PAX5), and IKAROS family of zinc finger 3 (IKZF3), and several oncogenes, such as MYB , Indeed, combinatory inhibition of BCR pathway and showed an additive antitumor IKZF effect.
Concomitant targeting BRD4-regulated several molecules may be a rational therapeutic strategy for targeting MCL.Proteolysis chimera (PROTACs) is an emerging strategy to promote the targeted degradation of proteins by inducing proximity between proteins E3 ubiquitin ligases and targets. Despite the success of many protein degradation by PROTACs has been shown, the elements that determine the breakdown of proteins targeted PROTAC unexplored.
Substance P antibody
20R-SP001
Fitzgerald
50 ul
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Description: Guinea Pig polyclonal Substance P antibody
Substance P antibody
20R-SP002
Fitzgerald
50 uL
EUR 609
Description: Guinea Pig polyclonal Substance P antibody
Substance P antibody
20-SR15
Fitzgerald
1 ml
EUR 195
Description: Rabbit polyclonal Substance P antibody
Substance P Antibody
45053-100ul
SAB
100ul
EUR 302.4
Substance P Antibody
45053-50ul
SAB
50ul
EUR 224.4
Substance P Antibody
E19-7522-1
EnoGene
50ug/50ul
EUR 145
Description: Available in various conjugation types.
Substance P Antibody
E19-7522-2
EnoGene
100ug/100ul
EUR 225
Description: Available in various conjugation types.
Substance P Antibody
DF6541
Affbiotech
200ul
EUR 420
Substance P Antibody
DF6541-100ul
Affinity Biosciences
100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)
Substance P Antibody
DF6541-200ul
Affinity Biosciences
200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)
Substance P Antibody
DF7522
Affbiotech
200ul
EUR 420
Substance P Antibody
DF7522-100ul
Affinity Biosciences
100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)
Substance P Antibody
DF7522-200ul
Affinity Biosciences
200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)
Substance P antibody
MBS530819-05mL
MyBiosource
0.5mL
EUR 1095
Substance P antibody
MBS530819-5x05mL
MyBiosource
5x0.5mL
EUR 4780
Substance P antibody
MBS534365-1mL
MyBiosource
1mL
EUR 305
Substance P antibody
MBS534365-5x1mL
MyBiosource
5x1mL
EUR 1215
Substance P antibody
MBS534548-INQUIRE
MyBiosource
INQUIRE
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Substance P antibody
MBS534624-005mL
MyBiosource
0.05mL
EUR 775
Substance P antibody
MBS534624-5x05mL
MyBiosource
5x0.5mL
EUR 3345
Substance P Antibody
MBS9607197-01mL
MyBiosource
0.1mL
EUR 260
Substance P Antibody
MBS9607197-02mL
MyBiosource
0.2mL
EUR 305
Substance P Antibody
MBS9607197-5x02mL
MyBiosource
5x0.2mL
EUR 1220
Substance P Antibody
MBS9608131-01mL
MyBiosource
0.1mL
EUR 260
Substance P Antibody
MBS9608131-02mL
MyBiosource
0.2mL
EUR 305
Substance P Antibody
MBS9608131-5x02mL
MyBiosource
5x0.2mL
EUR 1220
Substance P Antibody
MBS8516927-005mg
MyBiosource
0.05mg
EUR 235
Substance P Antibody
MBS8516927-01mg
MyBiosource
0.1mg
EUR 305
Substance P Antibody
MBS8516927-01mLAF405M
MyBiosource
0.1mL(AF405M)
EUR 465
Substance P Antibody
MBS8516927-01mLAF546
MyBiosource
0.1mL(AF546)
EUR 465
Substance P Antibody
MBS8516927-01mLAF750
MyBiosource
0.1mL(AF750)
EUR 465
Substance P Antibody
MBS9418447-005mL
MyBiosource
0.05mL
EUR 245
Substance P Antibody
MBS9418447-01mL
MyBiosource
0.1mL
EUR 305
Substance P Antibody
MBS9418447-5x01mL
MyBiosource
5x0.1mL
EUR 1230
Substance P antibody
Y150
Sceti
50 ul
EUR 512.4
Description: The Substance P antibody is available in Europe and for worldwide shipping via Gentaur.
Anti- Substance P 4-11 Antibody
GWB-8C0875
GenWay Biotech
0.05 ml
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Anti- Substance-P receptor Antibody
GWB-3283F7
GenWay Biotech
0.05 ml
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Anti- Substance-P receptor Antibody
GWB-FD898C
GenWay Biotech
0.05 ml
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Substance P (SP) Antibody
20-abx178494
Abbexa
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Substance P (SP) Antibody
abx178494-96tests
Abbexa
96 tests
EUR 275
Substance P (TAC1) Antibody
abx020654-100ug
Abbexa
100 ug
EUR 1053.6
Substance P (TAC1) Antibody
20-abx218815
Abbexa
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Substance P (TAC1) Antibody
abx130513-100l
Abbexa
100 µl
EUR 275
Substance P (TAC1) Antibody
20-abx130513
Abbexa
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10 ug
50 ug
100 ug
200 ug
1 mg
Substance P (TAC1) Antibody
abx130513-1ml
Abbexa
1 ml
EUR 750
Substance P (TAC1) Antibody
abx130513-200l
Abbexa
200 µl
EUR 337.5
Substance P Antibody HRP Conjugated
MBS9459730-01mL
MyBiosource
0.1mL
EUR 595
Substance P Antibody HRP Conjugated
MBS9459730-5x01mL
MyBiosource
5x0.1mL
EUR 2525
RAT ANTI SUBSTANCE P
MBS213959-01mL
MyBiosource
0.1mL
EUR 545
RAT ANTI SUBSTANCE P
MBS213959-5x01mL
MyBiosource
5x0.1mL
EUR 2275
Substance P polyclonal antibody
AP6027
Bioworld Biotech
50ul
EUR 275
Description: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Substance P polyclonal antibody
BZ16776
Bioworld Biotech
50ul
EUR 358
Description: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Substance P Conjugated Antibody
C45053
SAB
100ul
EUR 476.4
Substance P polyclonal antibody
E43P6027
EnoGene
100ul
EUR 225
Description: Available in various conjugation types.
Substance P polyclonal antibody
MBS566533-0025mL
MyBiosource
0.025mL
EUR 225
Substance P polyclonal antibody
MBS566533-01mL
MyBiosource
0.1mL
EUR 505
Substance P polyclonal antibody
MBS566533-5x01mL
MyBiosource
5x0.1mL
EUR 2240
Substance P Conjugated Antibody
MBS9453005-01mLAF350
MyBiosource
0.1mL(AF350)
EUR 480
Substance P Conjugated Antibody
MBS9453005-01mLAF405
MyBiosource
0.1mL(AF405)
EUR 480
Substance P Conjugated Antibody
MBS9453005-01mLAF488
MyBiosource
0.1mL(AF488)
EUR 480
Substance P Conjugated Antibody
MBS9453005-01mLAF555
MyBiosource
0.1mL(AF555)
EUR 480
Substance P Conjugated Antibody
MBS9453005-01mLBiotin
MyBiosource
0.1mL(Biotin)
EUR 480
Substance-P receptor (TACR1) Antibody
abx402285-100g
Abbexa
100 µg
EUR 400
Substance-P receptor (TACR1) Antibody
abx402285-1mg
Abbexa
1 mg
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Substance-P receptor (TACR1) Antibody
abx402285-20g
Abbexa
20 µg
EUR 287.5
Substance P Rabbit monoclonal antibody
BS40445
Bioworld Biotech
50ul
EUR 298
Description: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Substance P Rabbit Polyclonal Antibody
E10G22909
EnoGene
100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody
Substance-P receptor Polyclonal Antibody
42508
SAB
100μg
EUR 390
Substance-P receptor Polyclonal Antibody
42508-100ul
SAB
100ul
EUR 399.6
Substance-P receptor Polyclonal Antibody
MBS9415940-01mg
MyBiosource
0.1mg
EUR 350
Substance-P receptor Polyclonal Antibody
MBS9415940-5x01mg
MyBiosource
5x0.1mg
EUR 1420
Substance P (Human, Rat, Mouse) - Antibody
H-061-05
PHOENIX PEPTIDE
50 μl
EUR 238.68
Substance P (5-11) (Hepta Substance P)
MBS659385-1mg
MyBiosource
1mg
EUR 610
Substance P (5-11) (Hepta Substance P)
MBS659385-5x1mg
MyBiosource
5x1mg
EUR 2600
Polyclonal Antibody to Substance P (SP)
MBS2111869-01mL
MyBiosource
0.1mL
EUR 175
Polyclonal Antibody to Substance P (SP)
MBS2111869-02mL
MyBiosource
0.2mL
EUR 220
Polyclonal Antibody to Substance P (SP)
MBS2111869-05mL
MyBiosource
0.5mL
EUR 355
Polyclonal Antibody to Substance P (SP)
MBS2111869-1mL
MyBiosource
1mL
EUR 435
Polyclonal Antibody to Substance P (SP)
MBS2111869-5mL
MyBiosource
5mL
EUR 1185
Polyclonal Antibody to Substance P (SP)
MBS2008473-01mL
MyBiosource
0.1mL
EUR 175
Polyclonal Antibody to Substance P (SP)
MBS2008473-02mL
MyBiosource
0.2mL
EUR 220
Polyclonal Antibody to Substance P (SP)
MBS2008473-05mL
MyBiosource
0.5mL
EUR 355
Polyclonal Antibody to Substance P (SP)
MBS2008473-1mL
MyBiosource
1mL
EUR 435
Polyclonal Antibody to Substance P (SP)
MBS2008473-5mL
MyBiosource
5mL
EUR 1185
Polyclonal Antibody to Substance P (SP)
PAA393Ra01
Cloud-Clone
100ul
EUR 245
Substance P [p-Bz-Phe8]-([BPA8]-Substance P)
MBS658266-1mg
MyBiosource
1mg
EUR 610
Substance P [p-Bz-Phe8]-([BPA8]-Substance P)
MBS658266-5x1mg
MyBiosource
5x1mg
EUR 2600
Substance P (SP) Polyclonal Antibody (Human)
4-PAA393Hu01
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Substance P (SP)
Anti Substance P Serum (50 ul)
MBS406453-005mL
MyBiosource
0.05mL
EUR 660
Anti Substance P Serum (50 ul)
MBS406453-5x005mL
MyBiosource
5x0.05mL
EUR 2915
Rabbit anti-human Substance-P receptor polyclonal Antibody
MBS7004531-005mg
MyBiosource
0.05mg
EUR 190
Rabbit anti-human Substance-P receptor polyclonal Antibody
MBS7004531-01mg
MyBiosource
0.1mg
EUR 270
Rabbit anti-human Substance-P receptor polyclonal Antibody
MBS7004531-5x01mg
MyBiosource
5x0.1mg
EUR 1205
Substance P (17W7) Rabbit Monoclonal Antibody
E28M5114
EnoGene
100ul
EUR 295
[KO Validated] Substance P polyclonal antibody
BS78104
Bioworld Biotech
50ul
EUR 398
Description: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
(KO Validated) Substance P Polyclonal Antibody
E-AB-92319-120uL
Elabscience Biotech
120uL
EUR 360
Description: Unconjugated
(KO Validated) Substance P Polyclonal Antibody
E-AB-92319-200uL
Elabscience Biotech
200uL
EUR 580
Description: Unconjugated
(KO Validated) Substance P Polyclonal Antibody
E-AB-92319-60uL
Elabscience Biotech
60uL
EUR 220
Description: Unconjugated
(KO Validated) Substance P Polyclonal Antibody
E-AB-92319-each
Elabscience Biotech
each
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Description: Unconjugated
Substance P Polyclonal Antibody Cy3 Conjugated
MBS9459731-01mL
MyBiosource
0.1mL
EUR 595
Substance P Polyclonal Antibody Cy3 Conjugated
MBS9459731-5x01mL
MyBiosource
5x0.1mL
EUR 2525
Substance P Polyclonal Antibody Bio Conjugated
MBS9462067-01mL
MyBiosource
0.1mL
EUR 595
Substance P Polyclonal Antibody Bio Conjugated
MBS9462067-5x01mL
MyBiosource
5x0.1mL
EUR 2525
Substance P Rat Monoclonal Antibody (NC1/34)
MBS588031-05mL
MyBiosource
0.5mL
EUR 530
Substance P Rat Monoclonal Antibody (NC1/34)
MBS588031-5x05mL
MyBiosource
5x0.5mL
EUR 2150
Substance P Rat Monoclonal Antibody (NC1/34)
MBS588186-05mL
MyBiosource
0.5mL
EUR 545
Substance P Rat Monoclonal Antibody (NC1/34)
MBS588186-5x05mL
MyBiosource
5x0.5mL
EUR 2215
Substance P (SP) Polyclonal Antibody (Human), PE
4-PAA393Hu01-PE
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Substance P (SP). This antibody is labeled with PE.
Substance P (SP) Polyclonal Antibody (Human), APC
4-PAA393Hu01-APC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Substance P (SP). This antibody is labeled with APC.
Substance P (SP) Polyclonal Antibody (Human), Cy3
4-PAA393Hu01-Cy3
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Substance P (SP). This antibody is labeled with Cy3.
Substance P (SP) Polyclonal Antibody (Human), HRP
4-PAA393Hu01-HRP
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Substance P (SP). This antibody is labeled with HRP.
Rat Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098876-10x96Tests
MyBiosource
10x96Tests
EUR 1715
Rat Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098876-10x96TestsMBS2090686AbPairsSupportPack210x96Tests
MyBiosource
10x96Tests+MBS2090686(AbPairsSupportPack2,10x96Tests)
EUR 1835
Rat Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098876-5x96Tests
MyBiosource
5x96Tests
EUR 1080
Rat Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098876-5x96TestsMBS2090686AbPairsSupportPack25x96Tests
MyBiosource
5x96Tests+MBS2090686(AbPairsSupportPack2,5x96Tests)
EUR 1145
Substance P (SP) Polyclonal Antibody (Human), FITC
4-PAA393Hu01-FITC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Substance P (SP). This antibody is labeled with FITC.
Polyclonal antibody-Canine Substance-P receptor
PA-RA-07937
Nova Lifetech
100ug
EUR 400
Substance P
4010600.0005
Bachem
5 mg
EUR 93.24
Substance P
4010600.0025
Bachem
25 mg
EUR 374.12
Substance P
5-01969
CHI Scientific
4 x 5mg
EUR 270.27
Description: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Substance P
B6620-1
ApexBio
1 mg
EUR 166.8
Substance P
B6620-10
ApexBio
10 mg
EUR 459.6
Substance P
B6620-25
ApexBio
25 mg
EUR 961.2
Substance P
B6620-5
ApexBio
5 mg
EUR 88
Description: Others|Tachykinin
Substance P
GP14103
Neuromics
50 ul
EUR 278.4
Substance P
H-1890.0005
Bachem
5.0mg
EUR 181.2
Description: Sum Formula: C63H98N18O13S; CAS# [33507-63-0] net
Substance P
H-1890.0025
Bachem
25.0mg
EUR 618
Description: Sum Formula: C63H98N18O13S; CAS# [33507-63-0] net
Substance P
MBS352262-5x01mL
MyBiosource
5x0.1mL
EUR 1950
Substance P
MBS405776-5x05mg
MyBiosource
5x0.5mg
EUR 660
Substance P
MBS405776-5x25mg
MyBiosource
5x25mg
EUR 4210
Substance P
MBS826357-5x10mg
MyBiosource
5x10mg
EUR 1800
Substance P
MO15094
Neuromics
100 ug
EUR 459.6
Substance P
P14103
Neuromics
100 ug Blocking Peptide
EUR 66.5
Substance P
RA20064
Neuromics
100 ul
EUR 321.75
Rabbit anti-human Substance-P receptor polyclonal Antibody, FITC
MBS719756-005mg
MyBiosource
0.05mg
EUR 190
Rabbit anti-human Substance-P receptor polyclonal Antibody, FITC
MBS719756-01mg
MyBiosource
0.1mg
EUR 270
Rabbit anti-human Substance-P receptor polyclonal Antibody, FITC
MBS719756-5x01mg
MyBiosource
5x0.1mg
EUR 1205
Human Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098874-10x96Tests
MyBiosource
10x96Tests
EUR 1050
Human Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098874-10x96TestsMBS2090686AbPairsSupportPack210x96Tests
MyBiosource
10x96Tests+MBS2090686(AbPairsSupportPack2,10x96Tests)
EUR 1165
Human Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098874-5x96Tests
MyBiosource
5x96Tests
EUR 675
Human Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098874-5x96TestsMBS2090686AbPairsSupportPack25x96Tests
MyBiosource
5x96Tests+MBS2090686(AbPairsSupportPack2,5x96Tests)
EUR 745
Mouse Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098875-10x96Tests
MyBiosource
10x96Tests
EUR 1630
Mouse Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098875-10x96TestsMBS2090686AbPairsSupportPack210x96Tests
MyBiosource
10x96Tests+MBS2090686(AbPairsSupportPack2,10x96Tests)
EUR 1750
Mouse Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098875-5x96Tests
MyBiosource
5x96Tests
EUR 1030
Mouse Substance P (SP) Antibody Pair Kit (with Standard)
MBS2098875-5x96TestsMBS2090686AbPairsSupportPack25x96Tests
MyBiosource
5x96Tests+MBS2090686(AbPairsSupportPack2,5x96Tests)
EUR 1100
Substance-P receptor Polyclonal Conjugated Antibody
C42508
SAB
100ul
EUR 476.4
Substance-P Receptor Polyclonal Conjugated Antibody
MBS9450915-01mLAF350
MyBiosource
0.1mL(AF350)
EUR 480
Substance-P Receptor Polyclonal Conjugated Antibody
MBS9450915-01mLAF405
MyBiosource
0.1mL(AF405)
EUR 480
Substance-P Receptor Polyclonal Conjugated Antibody
MBS9450915-01mLAF488
MyBiosource
0.1mL(AF488)
EUR 480
Substance-P Receptor Polyclonal Conjugated Antibody
MBS9450915-01mLAF555
MyBiosource
0.1mL(AF555)
EUR 480
Substance-P Receptor Polyclonal Conjugated Antibody
MBS9450915-01mLBiotin
MyBiosource
0.1mL(Biotin)
EUR 480
Anti- Substance-K receptor Antibody
GWB-617536
GenWay Biotech
0.05 ml
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Substance P, Affinity Purified Antibody, guinea pig
MBS555350-01mL
MyBiosource
0.1mL
EUR 455
Substance P, Affinity Purified Antibody, guinea pig
MBS555350-5x01mL
MyBiosource
5x0.1mL
EUR 1895
Substance P (2-11)/Deca-Substance P
5-01976
CHI Scientific
4 x 5mg
EUR 245.7
Description: Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Substance P (3-11)/Nona-Substance P
5-01977
CHI Scientific
4 x 5mg
EUR 229.32
Description: Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
In this study, we developed the von Hippel-Lindau-cereblon (VHL-CRBN) heterodimerizing CRBN PROTACs which induces degradation, but not VHL. A quantitative proteomic analysis further revealed that VHL-CRBN heterodimerizing PROTACs CRBN induced degradation, but not well-known immunomodulatory drug (IMiD) neo-substrate, IKAROS family of zinc finger 1 (IKZF1) and -3 (IZKF3).