Sensitive detection of recurrent colorectal cancer (CRC) by measuring circulating tumor DNA (ctDNA) can increase the chance of a cure. This study compared the quantitative methylated ctDNA test with carcinoembryonic antigen (CEA) in the supervision arrangements for recurrence.Blood samples collected either for surveillance or within 12 months of confirmation of recurrence was tested for ctDNA (methylated branched-chain amino acid transaminase 1 [BCAT1] / Ikaros 1 family of zinc-finger proteins [IKZF1]) and CEA.

CtDNA optimal threshold is determined by receiver operating characteristic analysis, and performance tests for the detection of recurrence compared with CEA (5 threshold ng / mL) .the study cohort comprised 144 patients were eligible and including 50 recurrence events.

Sensitivity tests ctDNA are methylated to recurrence was 66.0% (95% confidence interval [CI], 57.1% -69.3%), which was significantly higher than the sensitivity of CEA (31.9%; 95% CI, 22.8% -36.6%; P <0.001). Sensitivity for inoperable recurrence (n = 20) was also higher (ctDNA, 60.0%; CEA, 20.0%; P = 0.01). specificity did not differ between tests (ctDNA, 97.9%; 95% CI, 93.2% -99.6%; CEA, 96.4%; 95% CI, 91.4% -99.0%).

When adjusting for other predictors of the presence of recurrence, ctDNA tests positive is an independent predictor (odds ratio, 155.7; 95% CI, 17.9 to 1360.6; P <0.001), whereas CEA did not (odds ratio, 2, 5; 95% CI, 0.3 to 20.6; P = .407) .the quantitative ctDNA test indicate superior sensitivity as compared with CEA without differences in specificity for detecting recurrent CRC. Longitudinal studies are guaranteed to further assess the utility (especially the survival benefit) of alcohol BCAT1 / IKZF1 ctDNA in surveillance of patients with CRC.

BRD4-Molecular Targets Set in Mantle Cell Lymphoma: Therapy Approach Target Insights.

Since bromodomain-containing protein 4 (BRD4) facilitating transcription of genes important for cell-cell specific neoplastic cancer types, BRD4-regulated molecule can also include a therapeutic target for mantle cell lymphoma (MCL), treatment-resistant subtype wildfire lymphoma.

In to the target BRD4-arranged directly reveal in MCL, we carried out with an integrated analysis by using the database and track the results of both the gene expression profile and chromatin immunoprecipitation with parallel sequencing to BRD4.Treatment with BRD4 inhibitor I-BET151 dose -dependent inhibitory effect on cell proliferation MCL cell lines. BRD4 found immediately arranged a series of genes involved in cell receptor B (BCR) signaling pathway, including linker-B cells (blnk), paired box 5 (PAX5), and IKAROS family of zinc finger 3 (IKZF3), and several oncogenes, such as MYB , Indeed, combinatory inhibition of BCR pathway and showed an additive antitumor IKZF effect.

Concomitant targeting BRD4-regulated several molecules may be a rational therapeutic strategy for targeting MCL.Proteolysis chimera (PROTACs) is an emerging strategy to promote the targeted degradation of proteins by inducing proximity between proteins E3 ubiquitin ligases and targets. Despite the success of many protein degradation by PROTACs has been shown, the elements that determine the breakdown of proteins targeted PROTAC unexplored.

Substance P Antibody
45053-100ul	SAB	100ul	EUR 302.4

Substance P Antibody
45053-50ul	SAB	50ul	EUR 224.4

Substance P antibody
20R-SP001	Fitzgerald	50 ul	EUR 457.2
Description: Guinea Pig polyclonal Substance P antibody

Substance P antibody
20R-SP002	Fitzgerald	50 uL	EUR 786
Description: Guinea Pig polyclonal Substance P antibody

Substance P antibody
20-SR15	Fitzgerald	1 ml	EUR 289.2
Description: Rabbit polyclonal Substance P antibody

Substance P antibody
10-S15A	Fitzgerald	500 ul	EUR 956.4
Description: Rat monoclonal Substance P antibody

Substance P Antibody
ABD7522	Lifescience Market	100 ug	EUR 525.6

Substance P antibody
Y150	Sceti	50 ul	EUR 512.4
Description: The Substance P antibody is available in Europe and for worldwide shipping via Gentaur.

Substance P
5-01969	CHI Scientific	4 x 5mg	Ask for price

Substance P
B6620-1	ApexBio	1 mg	EUR 166.8

Substance P
B6620-10	ApexBio	10 mg	EUR 459.6

Substance P
B6620-25	ApexBio	25 mg	EUR 961.2

Substance P
B6620-5	ApexBio	5 mg	EUR 280.8

Substance P
P14103	Neuromics	100 ug Blocking Peptide	EUR 175.2

Substance P
MO15094	Neuromics	100 ug	EUR 459.6

Substance P
GP14103	Neuromics	50 ul	EUR 278.4

Substance P
HY-P0201	MedChemExpress	25mg	EUR 804

Substance P
H-1890.0005	Bachem	5.0mg	EUR 181.2
Description: Sum Formula: C63H98N18O13S; CAS# [33507-63-0] net

Substance P
H-1890.0025	Bachem	25.0mg	EUR 618
Description: Sum Formula: C63H98N18O13S; CAS# [33507-63-0] net

Substance P
RA20064	Neuromics	100 ul	EUR 546

Human Substance P Peptide (amide salt)
SP15-P-1	Alpha Diagnostics	1 mg	EUR 196.8

Human Substance P Peptide (amide salt)
SP15-P-25	Alpha Diagnostics	25 mg	EUR 634.8

Human Substance P Peptide (amide salt)
SP15-P-5	Alpha Diagnostics	5 mg	EUR 343.2

Substance P (2-11)/Deca-Substance P
5-01976	CHI Scientific	4 x 5mg	Ask for price

Substance P (3-11)/Nona-Substance P
5-01977	CHI Scientific	4 x 5mg	Ask for price

Substance P (4-11)/Octa-Substance P
5-01978	CHI Scientific	4 x 5mg	Ask for price

Substance P (5-11)/Hepta-Substance P
5-01979	CHI Scientific	4 x 5mg	Ask for price

Substance P (6-11)/Hexa-Substance P
5-01980	CHI Scientific	4 x 5mg	Ask for price

Anti-Substance P 4-11 antibody
STJ16101254	St John's Laboratory	50 µl	EUR 644.4

Anti-Substance P 4-11 antibody
STJ16101387	St John's Laboratory	50 µl	EUR 644.4

Substance P Conjugated Antibody
C45053	SAB	100ul	EUR 476.4

Substance P (TAC1) Antibody
20-abx130513	Abbexa	EUR 510.00 EUR 159.60 EUR 1446.00 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Substance P (TAC1) Antibody
abx020654-100ug	Abbexa	100 ug	EUR 1053.6

Substance P (SP) Antibody
20-abx178494	Abbexa	EUR 1446.00 EUR 693.60	1 mg 200 ug

Substance P (TAC1) Antibody
20-abx218815	Abbexa	EUR 510.00 EUR 410.40	100 ug 50 ug

Substance P (6-11) / Hexa-Substance P Peptide
20-abx265865	Abbexa	EUR 427.20 EUR 644.40 EUR 343.20	10 mg 25 mg 5 mg

Substance P (4-11) / Octa-Substance P Peptide
20-abx266093	Abbexa	EUR 493.20 EUR 794.40 EUR 376.80	10 mg 25 mg 5 mg

Substance P (3-11) / Nona-Substance P Peptide
20-abx266191	Abbexa	EUR 526.80 EUR 861.60 EUR 393.60	10 mg 25 mg 5 mg

Substance P (2-11) / Deca-Substance P Peptide
20-abx266243	Abbexa	EUR 560.40 EUR 910.80 EUR 410.40	10 mg 25 mg 5 mg

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 336

[Arg3] Substance P
5-00040	CHI Scientific	4 x 5mg	Ask for price

[Gly11] Substance P
5-00200	CHI Scientific	4 x 5mg	Ask for price

[His11]Substance P
5-00206	CHI Scientific	4 x 5mg	Ask for price

[Nle11] Substance P
5-00251	CHI Scientific	4 x 5mg	Ask for price

[Pro9] Substance P
5-00280	CHI Scientific	4 x 5mg	Ask for price

[Sar9] Substance P
5-00306	CHI Scientific	4 x 5mg	Ask for price

[Tyr8] Substance P
5-00365	CHI Scientific	4 x 5mg	Ask for price

Biotin-Substance P
5-00821	CHI Scientific	4 x 5mg	Ask for price

Substance P Peptide
20-abx266313	Abbexa	EUR 594.00 EUR 978.00 EUR 427.20	10 mg 25 mg 5 mg

[Nle11]-Substance P
HY-P1506	MedChemExpress	10mg	EUR 486

Substance P-Pure
GP14110	Neuromics	100 ul	EUR 486

Biotinyl-Substance P
H-5666.0001	Bachem	1.0mg	EUR 297.6
Description: Sum Formula: C73H112N20O15S2; CAS# [87468-58-4] net

Biotinyl-Substance P
H-5666.0005	Bachem	5.0mg	EUR 1082.4
Description: Sum Formula: C73H112N20O15S2; CAS# [87468-58-4] net

(Tyr8)-Substance P
H-1915.0005	Bachem	5.0mg	EUR 327.6
Description: Sum Formula: C63H98N18O14S; CAS# [55614-10-3]

(Tyr8)-Substance P
H-1915.0025	Bachem	25.0mg	EUR 1197.6
Description: Sum Formula: C63H98N18O14S; CAS# [55614-10-3]

Pre-Sure ChIP Antibody Validation Kit
P-2031	EpiGentek	EUR 1241.46 EUR 503.80 EUR 833.80	96 reactions 48 reactions 96 reactions

Substance-P receptor Polyclonal Antibody
42508-100ul	SAB	100ul	EUR 399.6

Substance P Blocking Peptide
DF6541-BP	Affbiotech	1mg	EUR 234

Substance P Blocking Peptide
DF7522-BP	Affbiotech	1mg	EUR 234

[Tyr8, Nle11] Substance P
5-00366	CHI Scientific	4 x 5mg	Ask for price

Substance P reversed sequence
5-01970	CHI Scientific	4 x 5mg	Ask for price

Substance P, Free Acid
5-01971	CHI Scientific	4 x 5mg	Ask for price

Substance P-methyl ester
5-01972	CHI Scientific	4 x 5mg	Ask for price

Substance P (1-4)
5-01973	CHI Scientific	4 x 5mg	Ask for price

Substance P (1-7)
5-01974	CHI Scientific	4 x 5mg	Ask for price

Substance P (1-9)
5-01975	CHI Scientific	4 x 5mg	Ask for price

Substance P (7-11)
5-01981	CHI Scientific	4 x 5mg	Ask for price

Substance P (9-11)
5-01982	CHI Scientific	4 x 5mg	Ask for price

Substance P ELISA kit
55R-IB09650	Fitzgerald	96 wells	EUR 896.4
Description: ELISA kit for the detection of Substance P in the research laboratory

Substance P (SP) Protein
abx670081-5mg	Abbexa	5 mg	EUR 360

[Sar9] Substance P Peptide
20-abx266277	Abbexa	EUR 594.00 EUR 961.20 EUR 393.60	10 mg 25 mg 5 mg

[Gly11] Substance P Peptide
20-abx266304	Abbexa	EUR 594.00 EUR 978.00 EUR 427.20	10 mg 25 mg 5 mg

[Nle11] Substance P Peptide
20-abx266315	Abbexa	EUR 594.00 EUR 978.00 EUR 427.20	10 mg 25 mg 5 mg

[His11]Substance P Peptide
20-abx266319	Abbexa	EUR 594.00 EUR 978.00 EUR 427.20	10 mg 25 mg 5 mg

[Pro9] Substance P Peptide
20-abx266321	Abbexa	EUR 594.00 EUR 978.00 EUR 427.20	10 mg 25 mg 5 mg

[Tyr8] Substance P Peptide
20-abx266338	Abbexa	EUR 594.00 EUR 1078.80 EUR 427.20	10 mg 25 mg 5 mg

[Arg3] Substance P Peptide
20-abx266339	Abbexa	EUR 594.00 EUR 1078.80 EUR 427.20	10 mg 25 mg 5 mg

Substance P (Biotin) Peptide
20-abx266406	Abbexa	EUR 627.60 EUR 1045.20 EUR 460.80	10 mg 25 mg 5 mg

[D-Trp7,9,10]-Substance P
B6885-1	ApexBio	1 mg	EUR 340.8

Substance P (1-7)
HY-P1485	MedChemExpress	5mg	EUR 211.2

Substance P (7-11)
HY-P1492	MedChemExpress	10mg	EUR 253.2

Substance P (1-9)
HY-P1494	MedChemExpress	5mg	EUR 308.4

Substance P, Free Acid
HY-P1498	MedChemExpress	25mg	EUR 583.2

Substance P (7-11)
H-4555.0005	Bachem	5.0mg	EUR 151.2
Description: Sum Formula: C31H44N6O5S; CAS# [51165-05-0]

Substance P (7-11)
H-4555.0025	Bachem	25.0mg	EUR 501.6
Description: Sum Formula: C31H44N6O5S; CAS# [51165-05-0]

Substance P (4-11)
H-4680.0005	Bachem	5.0mg	EUR 240
Description: Sum Formula: C46H67N11O10S; CAS# [53749-60-3]

Substance P (4-11)
H-4680.0025	Bachem	25.0mg	EUR 849.6
Description: Sum Formula: C46H67N11O10S; CAS# [53749-60-3]

Substance P (2-11)
H-4775.0005	Bachem	5.0mg	EUR 385.2
Description: Sum Formula: C57H86N14O12S; CAS# [53749-61-4]

Substance P (2-11)
H-4775.0025	Bachem	25.0mg	EUR 1430.4
Description: Sum Formula: C57H86N14O12S; CAS# [53749-61-4]

Substance P (5-11)
H-5726.0005	Bachem	5.0mg	EUR 181.2
Description: Sum Formula: C41H60N10O9S; CAS# [51165-09-4] net

Substance P (5-11)
H-5726.0025	Bachem	25.0mg	EUR 471.6
Description: Sum Formula: C41H60N10O9S; CAS# [51165-09-4] net

Substance P (6-11)
H-5728.0005	Bachem	5.0mg	EUR 181.2
Description: Sum Formula: C36H52N8O7S; CAS# [51165-07-2]

Substance P (6-11)
H-5728.0025	Bachem	25.0mg	EUR 471.6
Description: Sum Formula: C36H52N8O7S; CAS# [51165-07-2]

Substance P (9-11)
H-5880.0250	Bachem	250.0mg	EUR 356.4
Description: Sum Formula: C13H26N4O3S·HCl; CAS# [40297-96-9]

Substance P (9-11)
H-5880.1000	Bachem	1.0g	EUR 993.6
Description: Sum Formula: C13H26N4O3S·HCl; CAS# [40297-96-9]

Substance P (1-9)
H-1880.0005	Bachem	5.0mg	EUR 327.6
Description: Sum Formula: C52H77N15O12; CAS# [57468-17-4]

Substance P (1-9)
H-1880.0025	Bachem	25.0mg	EUR 1197.6
Description: Sum Formula: C52H77N15O12; CAS# [57468-17-4]

Substance P (free acid)
H-1885.0005	Bachem	5.0mg	EUR 385.2
Description: Sum Formula: C63H97N17O14S; CAS# [71977-09-8]

Substance P (free acid)
H-1885.0025	Bachem	25.0mg	EUR 1430.4
Description: Sum Formula: C63H97N17O14S; CAS# [71977-09-8]

Substance P-methyl ester
H-1895.0005	Bachem	5.0mg	EUR 385.2
Description: Sum Formula: C64H99N17O14S; CAS# [76260-78-1]

Substance P-methyl ester
H-1895.0025	Bachem	25.0mg	EUR 1430.4
Description: Sum Formula: C64H99N17O14S; CAS# [76260-78-1]

Substance P (1-7)
H-1582.0005	Bachem	5.0mg	EUR 211.2
Description: Sum Formula: C41H65N13O10; CAS# [68060-49-1]

Substance P (1-7)
H-1582.0025	Bachem	25.0mg	EUR 733.2
Description: Sum Formula: C41H65N13O10; CAS# [68060-49-1]

Synthetic Substance P (SP)
4-SPA393Hu01	Cloud-Clone	EUR 496.32 EUR 256.80 EUR 1531.20 EUR 590.40 EUR 1060.80 EUR 408.00 EUR 3648.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Substance P expressed in: E.coli

EpiNext DNA Purification HT System
P-1063	EpiGentek	EUR 7227.06 EUR 127.60 EUR 234.30 EUR 1103.30 EUR 5052.30	480 ml 4 ml 8 ml 64 ml 480 ml

EpiQuik Hydroxymethylated DNA Immunoprecipitation (hMeDIP) Kit
P-1038	EpiGentek	EUR 2007.06 EUR 451.00 EUR 775.50 EUR 1399.20	96 Reactions 24 Reactions 48 Reactions 96 Reactions

EpiQuik Chromatin Immunoprecipitation (ChIP) Kit
P-2002	EpiGentek	EUR 1084.86 EUR 312.40 EUR 500.50 EUR 738.10	96 Reactions 24 Reactions 48 Reactions 96 Reactions

EpiQuik Tissue Chromatin Immunoprecipitation (ChIP) Kit
P-2003	EpiGentek	EUR 1084.86 EUR 312.40 EUR 500.50 EUR 738.10	96 Reactions 24 Reactions 48 Reactions 96 Reactions

Methylamp DNA Modification Kit
P-1001	EpiGentek	EUR 416.70 EUR 149.60 EUR 259.60	80 Reactions 40 Reactions 80 Reactions

FitAmp General Tissue Section DNA Isolation Kit
P-1003	EpiGentek	EUR 754.26 EUR 253.00 EUR 490.60	100 Samples 50 Samples 100 Samples

FitAmp Plasma/Serum DNA Isolation Kit
P-1004	EpiGentek	EUR 416.70 EUR 149.60 EUR 253.00	100 Samples 50 Samples 100 Samples

TuMinute PCR Clean-Up Kit
P-1005	EpiGentek	EUR 303.60 EUR 90.20 EUR 171.60	100 Samples 50 Samples 100 Samples

DNA Concentrator Kit
P-1006	EpiGentek	EUR 303.60 EUR 90.20 EUR 171.60	100 Samples 50 Samples 100 Samples

FitAmp Paraffin Tissue Section DNA Isolation Kit
P-1009	EpiGentek	EUR 702.06 EUR 239.80 EUR 454.30	100 Samples 50 Samples 100 Samples

Methylamp One-Step DNA Modification Kit
P-1010	EpiGentek	EUR 416.70 EUR 148.50 EUR 253.00	80 Samples 40 Samples 80 Samples

Methylamp Universal Methylated DNA Kit
P-1011	EpiGentek	EUR 684.66 EUR 292.60 EUR 442.20	20 Modifications 10 Modifications 20 Modifications

FitAmp Circulating DNA Quantification Kit
P-1012	EpiGentek	EUR 595.92 EUR 217.80 EUR 387.20	96 Assays 48 Assays 96 Assays

Methylamp Global DNA Methylation Quantification Ultra Kit
P-1014B	EpiGentek	EUR 1137.06 EUR 429.00 EUR 760.10	96 Assays 48 Assays 96 Assays

Methylamp Methylated DNA Capture (MeDIP) Kit
P-1015	EpiGentek	EUR 1050.06 EUR 424.60 EUR 712.80	48 Reactions 24 Reactions 48 Reactions

Methylamp Whole Cell Bisulfite Modification Kit
P-1016	EpiGentek	EUR 595.92 EUR 213.40 EUR 380.60	80 Samples 40 Samples 80 Samples

FitAmp Urine DNA Isolation Kit
P-1017	EpiGentek	EUR 474.12 EUR 171.60 EUR 292.60	100 Samples 50 Samples 100 Samples

FitAmp Blood and Cultured Cell DNA Extraction Kit
P-1018	EpiGentek	EUR 468.90 EUR 166.10 EUR 294.80	100 Samples 50 Samples 100 Samples

FitAmp General DNA Quantification Kit
P-1020	EpiGentek	EUR 361.02 EUR 126.50 EUR 213.40	96 Assays 48 Assays 96 Assays

SuperSense Methylated DNA Quantification Kit
P-1021	EpiGentek	EUR 1137.06 EUR 442.20 EUR 760.10	96 Assays 48 Assays 96 Assays

Methylamp MS-qPCR Fast Kit
P-1028	EpiGentek	EUR 595.92 EUR 213.40 EUR 380.60	200 Reactions 100 Reactions 200 Reactions

EpiQuik Quantitative PCR Fast Kit
P-1029	EpiGentek	EUR 595.92 EUR 213.40 EUR 380.60	200 Reactions 100 Reactions 200 Reactions

MethylFlash Global DNA Hydroxymethylation (5-hmC) ELISA Easy Kit (Colorimetric)
P-1032	EpiGentek	EUR 1067.46 EUR 396.00 EUR 696.30	96 reactions 48 reactions 96 reactions

MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric)
P-1034	EpiGentek	EUR 1050.06 EUR 387.20 EUR 712.80	96 Assays 48 Assays 96 Assays

MethylFlash Methylated DNA Quantification Kit (Fluorometric)
P-1035	EpiGentek	EUR 1084.86 EUR 424.60 EUR 738.10	96 Assays 48 Assays 96 Assays

MethylFlash Hydroxymethylated DNA 5-hmC Quantification Kit (Colorimetric)
P-1036	EpiGentek	EUR 1084.86 EUR 424.60 EUR 738.10	96 Assays 48 Assays 96 Assays

MethylFlash Hydroxymethylated DNA Quantification Kit (Fluorometric)
P-1037	EpiGentek	EUR 1137.06 EUR 463.10 EUR 775.50	96 Assays 48 Assays 96 Assays

MethylFlash Urine 5-Methylcytosine (5-mC) Quantification Kit (Colorimetric)
P-1039	EpiGentek	EUR 945.66 EUR 360.80 EUR 625.90	96 Assays 48 Assays 96 Assays

MethylFlash Urine 5-Methylcytosine (5-mC) Quantification Kit (Fluorometric)
P-1040	EpiGentek	EUR 945.66 EUR 360.80 EUR 625.90	96 Assays 48 Assays 96 Assays

MethylFlash 5-Formylcytosine (5-fC) DNA Quantification Kit (Colorimetric)
P-1041	EpiGentek	EUR 1137.06 EUR 442.20 EUR 760.10	96 Assays 48 Assays 96 Assays

EpiNext DNA Library Preparation Kit (Illumina)
P-1051	EpiGentek	EUR 1415.46 EUR 552.20 EUR 955.90	24 Reactions 12 Reactions 24 Reactions

EpiQuik MeDIP Ultra Kit
P-1052	EpiGentek	EUR 1206.66 EUR 466.40 EUR 810.70	48 Reactions 24 Reactions 48 Reactions

EpiNext High-Sensitivity DNA Library Preparation Kit (Illumina)
P-1053	EpiGentek	EUR 1415.46 EUR 552.20 EUR 955.90	24 Reactions 12 Reactions 24 Reactions

EpiNext Post-Bisulfite DNA Library Preparation Kit (Illumina)
P-1055	EpiGentek	EUR 1485.06 EUR 599.50 EUR 1006.50	24 Reactions 12 Reactions 24 Reactions

EpiNext Bisulfite Sequencing Kit (Illumina)
P-1056	EpiGentek	EUR 1798.26 EUR 625.90 EUR 1225.40	24 Reactions 12 Reactions 24 Reactions

EpiNext DNA Size Selection Kit
P-1059	EpiGentek	EUR 361.02 EUR 127.60 EUR 213.40	96 reactions 48 reactions 96 reactions

EpiQuik Circulating Cell-Free DNA Isolation Kit
P-1064	EpiGentek	EUR 416.70 EUR 148.50 EUR 253.00	50 Isolations 25 Isolations 50 Isolations

EpiQuik Circulating Cell-Free DNA (ccfDNA) Isolation Easy Kit
P-1065	EpiGentek	EUR 416.70 EUR 148.50 EUR 253.00	50 Isolations 25 Isolations 50 Isolations

EpiQuik Methyl-Histone H3K9 ChIP Kit
P-2006	EpiGentek	EUR 1050.06 EUR 442.20 EUR 699.60	48 Reactions 24 Reactions 48 Reactions

EpiQuik Methyl-Histone H3K4 ChIP Kit
P-2007	EpiGentek	EUR 1032.66 EUR 416.90 EUR 686.40	48 Reactions 24 Reactions 48 Reactions

EpiQuik Tissue Methyl-Histone H3K9 ChIP Kit
P-2008	EpiGentek	EUR 1050.06 EUR 442.20 EUR 699.60	48 Reactions 24 Reactions 48 Reactions

EpiQuik Tissue Methyl-Histone H3K4 ChIP Kit
P-2009	EpiGentek	EUR 1050.06 EUR 442.20 EUR 699.60	48 Reactions 24 Reactions 48 Reactions

EpiQuik Acetyl-Histone H3 ChIP Kit
P-2010	EpiGentek	EUR 1050.06 EUR 442.20 EUR 699.60	48 Reactions 24 Reactions 48 Reactions

EpiQuik Acetyl-Histone H4 ChIP Kit
P-2011	EpiGentek	EUR 1050.06 EUR 442.20 EUR 699.60	48 Reactions 24 Reactions 48 Reactions

EpiQuik Tissue Acetyl-Histone H3 ChIP Kit
P-2012	EpiGentek	EUR 1050.06 EUR 442.20 EUR 699.60	48 Reactions 24 Reactions 48 Reactions

EpiQuik Tissue Acetyl-Histone H4 ChIP Kit
P-2013	EpiGentek	EUR 1050.06 EUR 442.20 EUR 699.60	48 Reactions 24 Reactions 48 Reactions

EpiQuik Plant ChIP Kit
P-2014	EpiGentek	EUR 945.66 EUR 387.20 EUR 639.10	48 Reactions 24 Reactions 48 Reactions

EpiQuik Methyl-Histone H3K27 ChIP Kit
P-2015	EpiGentek	EUR 1067.46 EUR 490.60 EUR 710.60	48 Reactions 24 Reactions 48 Reactions

EpiQuik Tissue Methyl-Histone H3K27 ChIP Kit
P-2016	EpiGentek	EUR 1067.46 EUR 490.60 EUR 710.60	48 Reactions 24 Reactions 48 Reactions

EpiQuik Methyl-CpG Binding Domain Protein 2 ChIP Kit
P-2017	EpiGentek	EUR 1067.46 EUR 490.60 EUR 710.60	48 Reactions 24 Reactions 48 Reactions

EpiQuik Methylated DNA Immunoprecipitation Kit
P-2019	EpiGentek	EUR 1067.46 EUR 451.00 EUR 724.90	48 Reactions 24 Reactions 48 Reactions

EpiQuik Tissue Methylated DNA Immunoprecipitation Kit
P-2020	EpiGentek	EUR 1067.46 EUR 442.20 EUR 710.60	48 Reactions 24 Reactions 48 Reactions

ChromaFlash One-Step ChIP Kit
P-2025	EpiGentek	EUR 1067.46 EUR 451.00 EUR 724.90	96 reactions 48 reactions 96 reactions

ChromaFlash One-Step Magnetic ChIP Kit
P-2026	EpiGentek	EUR 1067.46 EUR 451.00 EUR 724.90	96 Reactions 48 Reactions 96 Reactions

ChromaFlash High-Sensitivity ChIP Kit
P-2027	EpiGentek	EUR 771.66 EUR 338.80 EUR 512.60	48 Reactions 24 Reactions 48 Reactions

EpiNext ChIP-Seq High-Sensitivity Kit (Illumina)
P-2030	EpiGentek	EUR 1798.26 EUR 712.80 EUR 1249.60	24 Reactions 12 Reactions 24 Reactions

EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit
P-3001	EpiGentek	EUR 1050.06 EUR 424.60 EUR 712.80	96 Assays 48 Assays 96 Assays

EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K4)
P-3002	EpiGentek	EUR 1067.46 EUR 437.80 EUR 724.90	96 Assays 48 Assays 96 Assays

EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K9)
P-3003	EpiGentek	EUR 1067.46 EUR 437.80 EUR 724.90	96 Assays 48 Assays 96 Assays

EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit (Fluorometric)
P-3004	EpiGentek	EUR 1067.46 EUR 429.00 EUR 710.60	96 Assays 48 Assays 96 Assays

EpiQuik Histone Methyltransferase Activity/Inhibition Assay Kit (H3K27)
P-3005	EpiGentek	EUR 1067.46 EUR 437.80 EUR 724.90	96 Assays 48 Assays 96 Assays

EpiQuik DNMT1 Activity/Inhibitor Screening Assay Core Kit
P-3006A	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik DNMT3B Activity/Inhibitor Screening Assay Core Kit
P-3007A	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik DNA Demethylase Activity/Inhibition Assay Ultra Kit
P-3008	EpiGentek	EUR 1032.66 EUR 454.30 EUR 686.40	96 Assays 48 Assays 96 Assays

EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric)
P-3009	EpiGentek	EUR 1067.46 EUR 437.80 EUR 724.90	96 Assays 48 Assays 96 Assays

EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Fluorometric)
P-3010	EpiGentek	EUR 1067.46 EUR 451.00 EUR 724.90	96 Assays 48 Assays 96 Assays

EpiQuik Dnmt1 Assay Kit
P-3011	EpiGentek	EUR 1067.46 EUR 512.60 EUR 724.90	96 Assays 48 Assays 96 Assays

EpiQuik Dnmt3A Assay Kit
P-3012	EpiGentek	EUR 1067.46 EUR 503.80 EUR 710.60	96 Assays 48 Assays 96 Assays

EpiQuik Dnmt3B Assay Kit
P-3013	EpiGentek	EUR 1067.46 EUR 503.80 EUR 710.60	96 Assays 48 Assays 96 Assays

EpiQuik In Situ Histone H3K27 Tri-Methylation Assay Kit
P-3014T	EpiGentek	EUR 1276.26 EUR 503.80 EUR 858.00	2x96 assays 96 Assays 2x96 assays

EpiQuik In Situ Histone H3K4 Methylation Assay Kit
P-3015	EpiGentek	EUR 1276.26 EUR 503.80 EUR 858.00	2x96 assays 96 Assays 2x96 assays

EpiQuik In Situ Histone H3K9 Methylation Assay Kit
P-3016	EpiGentek	EUR 1276.26 EUR 503.80 EUR 858.00	2x96 assays 96 Assays 2x96 assays

EpiQuik Global Histone H3K4 Methylation Assay Kit
P-3017	EpiGentek	EUR 1067.46 EUR 477.40 EUR 710.60	96 Assays 48 Assays 96 Assays

EpiQuik Global Histone H3K9 Methylation Assay Kit
P-3018	EpiGentek	EUR 1067.46 EUR 477.40 EUR 710.60	96 Assays 48 Assays 96 Assays

EpiQuik DNA Demethylase Activity/Inhibition Assay Kit
P-3019	EpiGentek	EUR 1067.46 EUR 477.40 EUR 710.60	96 Assays 48 Assays 96 Assays

EpiQuik Global Histone H3K27 Methylation Assay Kit
P-3020	EpiGentek	EUR 1067.46 EUR 477.40 EUR 710.60	96 Assays 48 Assays 96 Assays

EpiQuik Global Di-Methyl Histone H3K4 Quantification Kit (Colorimetric)
P-3022	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Di-Methyl Histone H3K4 Quantification Kit (Fluorometric)
P-3023	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Mono-Methyl Histone H3K4 Quantification Kit (Colorimetric)
P-3024	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Mono-Methyl Histone H3K4 Quantification Kit (Fluorometric)
P-3025	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Tri-Methyl Histone H3K4 Quantification Kit (Colorimetric)
P-3026	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Tri-Methyl Histone H3K4 Quantification Kit (Fluorometric)
P-3027	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Mono-Methyl Histone H3K9 Quantification Kit (Colorimetric)
P-3030	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Mono-Methyl Histone H3K9 Quantification Kit (Fluorometric)
P-3031	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Di-Methyl Histone H3K9 Quantification Kit (Colorimetric)
P-3032	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Di-Methyl Histone H3K9 Quantification Kit (Fluorometric)
P-3033	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Tri-Methyl Histone H3K9 Quantification Kit (Colorimetric)
P-3034	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Tri-Methyl Histone H3K9 Quantification Kit (Fluorometric)
P-3035	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Mono-Methyl Histone H3K27 Quantification Kit (Colorimetric)
P-3038	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Mono-Methyl Histone H3K27 Quantification Kit (Fluorometric)
P-3039	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Di-Methyl Histone H3K27 Quantification Kit (Colorimetric)
P-3040	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

EpiQuik Global Di-Methyl Histone H3K27 Quantification Kit (Fluorometric)
P-3041	EpiGentek	EUR 945.66 EUR 333.30 EUR 625.90	96 Assays 48 Assays 96 Assays

In this study, we developed the von Hippel-Lindau-cereblon (VHL-CRBN) heterodimerizing CRBN PROTACs which induces degradation, but not VHL. A quantitative proteomic analysis further revealed that VHL-CRBN heterodimerizing PROTACs CRBN induced degradation, but not well-known immunomodulatory drug (IMiD) neo-substrate, IKAROS family of zinc finger 1 (IKZF1) and -3 (IZKF3).