Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation.

Cells CD4 + T helper cells able to differentiate into several subsets effector perform diverse functions during the adaptive immune response. Each subset differentiation is regulated, largely, by environmental cytokine signaling and subsequent activation of downstream transcription factor network of cell-intrinsic.

Ikaros zinc finger (IkZF) transcription factor known regulator of the development of immune cells, including CD4 + T cell subset Over the past decade, members of the family IkZF also been involved in the differentiation and function of T helper cell subset of individuals, including the T helper 1 (THHHFH ) and regulatory (Treg) cells T. Now, an increasing body of literature suggests that cell-specific cytokine different environment which is responsible for the development of any part results in differential expression IkZF factor of the entire population of T helper.

Interestingly, recent studies have shown that members of IkZF affects T helper differentiation inside the feed-forward mode through the regulatory cytokine-signaling pathways are the same. Here, we review the increasingly important role for IkZF transcription factor in the differentiation of effector CD4 + T helper cell subsets.

Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation.
Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation.

Assessing Relevance of Functional Variants in IKAROS Family Zinc Finger Protein 1 (IKZF1) in Cohort Patients With Primary Immunodeficiency.

common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency. Patients with CVID are susceptible to recurrent bacterial infections because of a failure of adequate immunoglobulin production. monogenetic defects have been identified in ~ 25% of patients with CVID.

More recently, mutations in IKZF1, encoding zinc-finger transcription factor IKAROS widely expressed in hematopoietic cells, has been associated with CVID like phenotype. Here we describe 11 patients with heterozygous variant IKZF1 of eight different families with autosomal dominant CVID and two siblings with a variant IKZF1 with inflammatory bowel disease (IBD). This study shows that the mutation affects the DNA binding domain IKAROS can disrupt the interaction with the target DNA sequence so as to prevent and localization pericentromeric heterochromatin (HC-PC) protein. Our results also indicate a decrease in localization pericentromeric of IKAROS by overexpression of truncated variants, due to mature stop codon in IKZF1.

We also describe additional variant in TNFSF10, encoding Tumor Necrosis Factor Related Apoptosis Encouraging ligand (TRAIL), also served in the individuals of A. Our Families results show that these variants can disrupt TRAIL-induced apoptosis in the target cell line and forbid the activation of NF by TRAIL and can act as a modifier in Family A
We report a new variant in IKZF1 associated with IKAROS haploinsufficiency in patients with familial immune thrombocytopenia (ITP). IKAROS, encoded by the gene IKZF1, a zinc-finger transcription factor hematopoietic can directly bind to DNA.

Biotin - Gastrin (1-17)

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Description: Rabbit Polyclonal Antibody for Sox-17 Antibody (SOX17) detection. Tested with WB in Human, Mouse.

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Description: Gastrin 17 Antigen, Host/Source: Synthetic. Matched Pair: HM683 (detection).

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Anti-Gastrin antibody

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Description: Unconjugated Mouse monoclonal to Gastrin (AS1A17)

Anti-Gastrin antibody

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Description: Rabbit polyclonal to Gastrin.

anti- Gastrin antibody

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Description: Antibody raised against Gastrin

Anti-Gastrin antibody

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Anti-Cytokeratin 17 Rabbit Monoclonal Antibody

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Description: rabbit monospecific clonal antibodies for ihc-p application; concentrated

Gastrin I (human)

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miRZip-17 anti-miR-17 microRNA construct

MZIP17-PA-1 Bacterial Streak
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Gastrin 17 Antigen (HM682 or HM683)

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EUR 1686
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17-Hydroxyprogesterone (17-OHP) ELISA Kit

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Description: A competitive inhibition quantitative ELISA assay kit for detection of 17-Hydroxyprogesterone (17-OHP) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rabbit Anti Gastrin Polyclonal Antibody

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General 17-Hydroxyprogesterone (17-OHP) ELISA Kit

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General 17-Hydroxyprogesterone (17-OHP) ELISA Kit

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Gastrin Releasing Peptide (GRP) (1-16) (porcine)

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[Leu15]-Gastrin I (human)

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17?-Hydroxywortmannin

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17-AAG

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Gastrin Antibody

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Gastrin Antibody

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EUR 304
Description: Gastrin Antibody detects endogenous levels of total Gastrin.

Gastrin Antibody

ABF0593 100 ug
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Gastrin Antibody

ABF5352 100 ug
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Gastrin Antibody

AF0593 200ul
EUR 304
Description: Gastrin Antibody detects endogenous levels of Gastrin.

Gastrin antibody

20R-2560 50 uL
EUR 532
Description: Guinea Pig polyclonal Gastrin antibody

Gastrin antibody

20-GR03 1 ml
EUR 273
Description: Rabbit polyclonal Gastrin antibody

Gastrin antibody

20R-GR002 250 uL
EUR 539
Description: Rabbit polyclonal Gastrin antibody

Gastrin antibody

70R-31204 100 ug
EUR 327
Description: Rabbit polyclonal Gastrin antibody

Gastrin antibody

70R-49765 100 ul
EUR 244
Description: Purified Polyclonal Gastrin antibody

YAP-TEAD Inhibitor 1 (Peptide 17)

A1149-1 1 mg
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Gastrin-1, human

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Gastrin-1, human

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IL-17 Interleukin-17 Human Recombinant Protein

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Description: Interleukin-17A Human Recombinant produced in E.Coli is a homodimeric, non-glycosylated polypeptide chain containing a total of 264 amino acids (2 chains of 132 aa) and having a molecular mass of 31kDa.  ;The IL-17 is purified by proprietary chromatographic techniques.

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Description: Rabbit polyclonal to Cytokeratin 17.

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Description: Antibody raised against Cytokeratin 17

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Anti-Cytokeratin 17 antibody

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Anti-Cytokeratin 17 antibody

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Anti-IL-17 antibody

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Anti-EDG-1 Antibody

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Anti-ROBO-1 Antibody

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Anti-TFIIIB90-1 Antibody

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Anti-Atrophin-1 Antibody

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Description: Rabbit Polyclonal Antibody for CNG-1 Antibody (CNGA1) detection. Tested with WB in Human, Mouse, Rat.

We show that the variants identified IKZF1 (p.His195Arg) alter histidine residues absolutely conserved required for folding of the three zinc-finger protein IKAROS, lead to the loss of the characteristics of nuclear immunofluorescence staining pattern. In our case, genetic testing is essential for diagnosis IKAROS haploinsufficiency, the presentation of which are known, including infections, aberrant hematopoiesis, leukemia, and age-related decline in humoral immunity. Our family studies underscore that, after infection, ITP is the most common clinical manifestation of both IKAROS haploinsufficiency.