Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation.

Cells CD4 + T helper cells able to differentiate into several subsets effector perform diverse functions during the adaptive immune response. Each subset differentiation is regulated, largely, by environmental cytokine signaling and subsequent activation of downstream transcription factor network of cell-intrinsic.

Ikaros zinc finger (IkZF) transcription factor known regulator of the development of immune cells, including CD4 + T cell subset Over the past decade, members of the family IkZF also been involved in the differentiation and function of T helper cell subset of individuals, including the T helper 1 (THHHFH ) and regulatory (Treg) cells T. Now, an increasing body of literature suggests that cell-specific cytokine different environment which is responsible for the development of any part results in differential expression IkZF factor of the entire population of T helper.

Interestingly, recent studies have shown that members of IkZF affects T helper differentiation inside the feed-forward mode through the regulatory cytokine-signaling pathways are the same. Here, we review the increasingly important role for IkZF transcription factor in the differentiation of effector CD4 + T helper cell subsets.

Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation.
Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation.

Assessing Relevance of Functional Variants in IKAROS Family Zinc Finger Protein 1 (IKZF1) in Cohort Patients With Primary Immunodeficiency.

common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency. Patients with CVID are susceptible to recurrent bacterial infections because of a failure of adequate immunoglobulin production. monogenetic defects have been identified in ~ 25% of patients with CVID.

More recently, mutations in IKZF1, encoding zinc-finger transcription factor IKAROS widely expressed in hematopoietic cells, has been associated with CVID like phenotype. Here we describe 11 patients with heterozygous variant IKZF1 of eight different families with autosomal dominant CVID and two siblings with a variant IKZF1 with inflammatory bowel disease (IBD). This study shows that the mutation affects the DNA binding domain IKAROS can disrupt the interaction with the target DNA sequence so as to prevent and localization pericentromeric heterochromatin (HC-PC) protein. Our results also indicate a decrease in localization pericentromeric of IKAROS by overexpression of truncated variants, due to mature stop codon in IKZF1.

We also describe additional variant in TNFSF10, encoding Tumor Necrosis Factor Related Apoptosis Encouraging ligand (TRAIL), also served in the individuals of A. Our Families results show that these variants can disrupt TRAIL-induced apoptosis in the target cell line and forbid the activation of NF by TRAIL and can act as a modifier in Family A
We report a new variant in IKZF1 associated with IKAROS haploinsufficiency in patients with familial immune thrombocytopenia (ITP). IKAROS, encoded by the gene IKZF1, a zinc-finger transcription factor hematopoietic can directly bind to DNA.

Gastrin 17 (G-17) Antibody
MBS569519-1mg 1mg
EUR 1080

Gastrin 17 (G-17) Antibody
MBS569519-5x1mg 5x1mg
EUR 4660

Anti- Gastrin Antibody
GWB-6A70AE 1 ml Ask for price

anti- Gastrin antibody
FNab03355 100µg
EUR 702
Description: Antibody raised against Gastrin

Anti Gastrin-17-C terminal mouse monoclonal antibody
MBS157959-01mL 0.1mL
EUR 350

Anti Gastrin-17-C terminal mouse monoclonal antibody
MBS157959-5x01mL 5x0.1mL
EUR 1250

Anti Gastrin-17-N terminal mouse monoclonal antibody
MBS157960-01mL 0.1mL
EUR 350

Anti Gastrin-17-N terminal mouse monoclonal antibody
MBS157960-5x01mL 5x0.1mL
EUR 1250

OAEF00738-1MG - Gastrin 17 (G-17) Antibody
OAEF00738-1MG 1mg
EUR 1112

OAEF00779-1MG - Gastrin 17 (G-17) Antibody
OAEF00779-1MG 1mg
EUR 1112

OAEF00780-1MG - Gastrin 17 (G-17) Antibody
OAEF00780-1MG 1mg
EUR 1112

OAEF00781-1MG - Gastrin 17 (G-17) Antibody
OAEF00781-1MG 1mg
EUR 1112

Gastrin 1, Antibody
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Gastrin 1, Antibody
GWB-3569F6 1 ml Ask for price

Anti- Gastrin/ CCK Antibody
GWB-8D712D 0.05 ml Ask for price

Gastrin 17 Antigen (HM682)
VAng-Cr3882-1mg 1 mg
EUR 2023.2
Description: Gastrin 17 Antigen, Host/Source: Synthetic. Matched Pair: HM682 (detection).

Gastrin 17 Antigen (HM683)
VAng-Cr3884-1mg 1 mg
EUR 2023.2
Description: Gastrin 17 Antigen, Host/Source: Synthetic. Matched Pair: HM683 (detection).

Gastrin Antibody
8C0205 50ug
EUR 368
Description: Gastrin Antibody

Gastrin Antibody
33384-100ul 100ul
EUR 302.4

Gastrin Antibody
33384-50ul 50ul
EUR 224.4

Gastrin antibody
70R-49765 100 ul
EUR 242
Description: Purified Polyclonal Gastrin antibody

Gastrin antibody
70R-31204 100 ug
EUR 294
Description: Rabbit polyclonal Gastrin antibody

Gastrin Antibody
ABF0593 100 ug
EUR 525.6

Gastrin Antibody
ABF5352 100 ug
EUR 525.6

Gastrin antibody
20R-2560 50 uL
EUR 489
Description: Guinea Pig polyclonal Gastrin antibody

Gastrin antibody
20R-GR002 250 uL
EUR 454
Description: Rabbit polyclonal Gastrin antibody

Gastrin antibody
20-GR03 1 ml
EUR 225
Description: Rabbit polyclonal Gastrin antibody

Gastrin Antibody
AF5352 200ul
EUR 420

Gastrin Antibody
AF5352-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

Gastrin Antibody
AF5352-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

Gastrin Antibody
AF0593 200ul
EUR 420

Gastrin Antibody
AF0593-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

Gastrin Antibody
AF0593-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

Gastrin antibody
CAF50126-100ug 100ug
EUR 364

Gastrin Antibody
C0205-100ul 100μl
EUR 217
Description: Gastrin Rabbit Polyclonal Antibody

Gastrin Antibody
C0205-50ul 50μl
EUR 143.5
Description: Gastrin Rabbit Polyclonal Antibody

Gastrin Antibody
GWB-B6B24B 0.5 ml Ask for price

Gastrin Antibody
GWB-383733 0.05 ml Ask for price

Gastrin Antibody
E11-0205C 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Gastrin Antibody
E18-5352-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

Gastrin Antibody
E18-5352-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Gastrin Antibody
E033384 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Gastrin Antibody
E18-0593-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

Gastrin Antibody
E18-0593-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Gastrin Antibody
E38PA9623 100ul
EUR 225
Description: Available in various conjugation types.

Gastrin Antibody
E38PA9685 100ul
EUR 225
Description: Available in various conjugation types.

Gastrin Antibody
MBS5314385-01mL 0.1mL
EUR 470

Gastrin Antibody
MBS5314385-5x01mL 5x0.1mL
EUR 1955

Gastrin antibody
MBS535166-1mL 1mL
EUR 335

Gastrin antibody
MBS535166-5x1mL 5x1mL
EUR 1350

Gastrin antibody
MBS536321-025mL 0.25mL
EUR 730

Gastrin antibody
MBS536321-5x025mL 5x0.25mL
EUR 3135

Gastrin Antibody
MBS8584424-01mL 0.1mL
EUR 305

Gastrin Antibody
MBS8584424-01mLAF405L 0.1mL(AF405L)
EUR 465

Gastrin Antibody
MBS8584424-01mLAF405S 0.1mL(AF405S)
EUR 465

Gastrin Antibody
MBS8584424-01mLAF610 0.1mL(AF610)
EUR 465

Gastrin Antibody
MBS8584424-01mLAF635 0.1mL(AF635)
EUR 465

Gastrin Antibody
MBS8584486-01mL 0.1mL
EUR 305

Gastrin Antibody
MBS8584486-01mLAF405L 0.1mL(AF405L)
EUR 465

Gastrin Antibody
MBS8584486-01mLAF405S 0.1mL(AF405S)
EUR 465

Gastrin Antibody
MBS8584486-01mLAF610 0.1mL(AF610)
EUR 465

Gastrin Antibody
MBS8584486-01mLAF635 0.1mL(AF635)
EUR 465

Gastrin Antibody
MBS9601524-01mL 0.1mL
EUR 260

Gastrin Antibody
MBS9601524-02mL 0.2mL
EUR 305

Gastrin Antibody
MBS9601524-5x02mL 5x0.2mL
EUR 1220

Gastrin Antibody
MBS9600443-01mL 0.1mL
EUR 260

Gastrin Antibody
MBS9600443-02mL 0.2mL
EUR 305

Gastrin Antibody
MBS9600443-5x02mL 5x0.2mL
EUR 1220

Gastrin Antibody
MBS9232637-01mL 0.1mL
EUR 415

Gastrin Antibody
MBS9232637-5x01mL 5x0.1mL
EUR 1841

Gastrin Antibody
MBS8511000-005mg 0.05mg
EUR 235

Gastrin Antibody
MBS8511000-01mg 0.1mg
EUR 305

Gastrin Antibody
MBS8511000-01mLAF405M 0.1mL(AF405M)
EUR 465

Gastrin Antibody
MBS8511000-01mLAF546 0.1mL(AF546)
EUR 465

Gastrin Antibody
MBS8511000-01mLAF750 0.1mL(AF750)
EUR 465

Gastrin antibody
MBS833321-005mL 0.05mL
EUR 785

Gastrin antibody
MBS833321-5x05mL 5x0.5mL
EUR 3370

Gastrin Antibody
MBS854021-01mg 0.1mg
EUR 305

Gastrin Antibody
MBS854021-01mLAF405L 0.1mL(AF405L)
EUR 465

Gastrin Antibody
MBS854021-01mLAF405S 0.1mL(AF405S)
EUR 465

Gastrin Antibody
MBS854021-01mLAF610 0.1mL(AF610)
EUR 465

Gastrin Antibody
MBS854021-01mLAF635 0.1mL(AF635)
EUR 465

Gastrin Antibody
MBS8511983-005mg 0.05mg
EUR 235

Gastrin Antibody
MBS8511983-01mg 0.1mg
EUR 305

Gastrin Antibody
MBS8511983-01mLAF405M 0.1mL(AF405M)
EUR 465

Gastrin Antibody
MBS8511983-01mLAF546 0.1mL(AF546)
EUR 465

Gastrin Antibody
MBS8511983-01mLAF750 0.1mL(AF750)
EUR 465

Gastrin Antibody
MBS9402805-005mL 0.05mL
EUR 245

Gastrin Antibody
MBS9402805-01mL 0.1mL
EUR 305

Gastrin Antibody
MBS9402805-5x01mL 5x0.1mL
EUR 1230

Gastrin Antibody
MBS9504608-005mL 0.05mL
EUR 285

Gastrin Antibody
MBS9504608-01mL 0.1mL
EUR 385

Gastrin Antibody
MBS9504608-5x01mL 5x0.1mL
EUR 1590

Biotin - Gastrin (1-17)
5-00788 4 x 1mg
EUR 171.99
Description: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

Gastrin 17 (G-17) Antigen >95%
MBS569567-1mg 1mg
EUR 935

Gastrin 17 (G-17) Antigen >95%
MBS569567-5x1mg 5x1mg
EUR 4005

Gastrin 17 (G-17) Antigen >95%
MBS569568-1mg 1mg
EUR 935

Gastrin 17 (G-17) Antigen >95%
MBS569568-5x1mg 5x1mg
EUR 4005

Gastrin 17 (G-17) Antigen >95%
MBS569836-1mg 1mg
EUR 935

Gastrin 17 (G-17) Antigen >95%
MBS569836-5x1mg 5x1mg
EUR 4005

Gastrin (GT) Antibody
abx131060-100l 100 µl
EUR 812.5

Gastrin (GT) Antibody
20-abx131060
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Gastrin (GT) Antibody
abx131060-20l 20 µl
EUR 287.5

Gastrin (GT) Antibody
abx131060-50l 50 µl
EUR 362.5

Gastrin (GT) Antibody
20-abx176568
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Gastrin (GT) Antibody
abx176568-1096tests 10 × 96 tests
EUR 712.5

Gastrin (GT) Antibody
abx176568-596tests 5 × 96 tests
EUR 325

Gastrin (GT) Antibody
abx176568-96tests 96 tests
EUR 262.5

Gastrin (GT) Antibody
20-abx176569
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Gastrin (GT) Antibody
abx176569-1096tests 10 × 96 tests
EUR 712.5

Gastrin (GT) Antibody
abx176569-596tests 5 × 96 tests
EUR 325

Gastrin (GT) Antibody
abx176569-96tests 96 tests
EUR 262.5

Gastrin (GT) Antibody
20-abx176570
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  • 200 ug
  • 1 mg

Gastrin (GT) Antibody
20-abx176571
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  • 200 ug
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Gastrin (GT) Antibody
20-abx172525
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  • 200 ug
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Gastrin (GT) Antibody
abx172525-1ml 1 ml
EUR 750

Gastrin (GT) Antibody
20-abx172526
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  • 200 ug
  • 1 mg

Gastrin (GT) Antibody
abx172526-1ml 1 ml
EUR 812.5

Gastrin (GT) Antibody
20-abx172527
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  • 200 ug
  • 1 mg

Gastrin (GT) Antibody
abx172527-1ml 1 ml
EUR 850

Gastrin (GT) Antibody
20-abx172528
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  • 200 ug
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Gastrin (GT) Antibody
abx100041-100l 100 µl
EUR 275

Gastrin (GT) Antibody
20-abx100041
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Gastrin (GT) Antibody
abx100041-1ml 1 ml
EUR 775

Gastrin (GT) Antibody
abx100041-200l 200 µl
EUR 350

Gastrin (GT) Antibody
abx100042-100l 100 µl
EUR 262.5

Gastrin (GT) Antibody
20-abx100042
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  • 10 ug
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  • 1 mg

Gastrin (GT) Antibody
abx100042-1ml 1 ml
EUR 712.5

Gastrin (GT) Antibody
abx100042-200l 200 µl
EUR 325

Gastrin (GT) Antibody
abx100043-100l 100 µl
EUR 262.5

Gastrin (GT) Antibody
20-abx100043
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  • 10 ug
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  • 1 mg

Gastrin (GT) Antibody
abx100043-1ml 1 ml
EUR 725

Gastrin (GT) Antibody
abx100043-200l 200 µl
EUR 337.5

Human Gastrin Antibody
10901-05011 150 ug
EUR 175

Rat Gastrin I/gastrin-17 ELISA kit
E01A13601 96T
EUR 700
Description: ELISA

Rat Gastrin I/gastrin-17 ELISA kit
E02G0416-48wellsplate 48 wells plate
EUR 280

Rat Gastrin I/gastrin-17 ELISA kit
E02G0416-96wellsplate 96 wells plate
EUR 405

human anti-human gastrin-17（G17） mAb（1XH）
E409C25-hA100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human gastrin-17（G17） mAb（2MH）
E409C25-hB100 100μL
EUR 395
Description: Available in various conjugation types.

mouse anti-human gastrin-17（G17） mAb（1XM）
E409C25-mA100 100μL
EUR 395
Description: Available in various conjugation types.

mouse anti-human gastrin-17（G17） mAb（2MM）
E409C25-mB100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human gastrin-17(G17) mAb(1XH)
E4A09H06-hA 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human gastrin-17(G17) mAb(2MH)
E4A09H06-hB 50ug
EUR 255
Description: Available in various conjugation types.

Human anti-Human gastrin-17 (G17) mAb (1XH)
MBS8576827-005mg 0.05mg
EUR 325

Human anti-Human gastrin-17 (G17) mAb (1XH)
MBS8576827-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human gastrin-17 (G17) mAb (1XH)
MBS8576827-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human gastrin-17 (G17) mAb (1XH)
MBS8576827-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human gastrin-17 (G17) mAb (1XH)
MBS8576827-01mLAF635 0.1mL(AF635)
EUR 565

Human anti-Human gastrin-17 (G17) mAb (2MH)
MBS8576828-005mg 0.05mg
EUR 325

Human anti-Human gastrin-17 (G17) mAb (2MH)
MBS8576828-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human gastrin-17 (G17) mAb (2MH)
MBS8576828-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human gastrin-17 (G17) mAb (2MH)
MBS8576828-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human gastrin-17 (G17) mAb (2MH)
MBS8576828-01mLAF635 0.1mL(AF635)
EUR 565

Mouse anti-Human gastrin-17 (G17) mAb (1XM)
MBS8576829-005mg 0.05mg
EUR 325

Mouse anti-Human gastrin-17 (G17) mAb (1XM)
MBS8576829-01mLAF405L 0.1mL(AF405L)
EUR 565

Mouse anti-Human gastrin-17 (G17) mAb (1XM)
MBS8576829-01mLAF405S 0.1mL(AF405S)
EUR 565

Mouse anti-Human gastrin-17 (G17) mAb (1XM)
MBS8576829-01mLAF610 0.1mL(AF610)
EUR 565

Mouse anti-Human gastrin-17 (G17) mAb (1XM)
MBS8576829-01mLAF635 0.1mL(AF635)
EUR 565

Mouse anti-Human gastrin-17 (G17) mAb (2MM)
MBS8576830-005mg 0.05mg
EUR 325

Mouse anti-Human gastrin-17 (G17) mAb (2MM)
MBS8576830-01mLAF405L 0.1mL(AF405L)
EUR 565

Mouse anti-Human gastrin-17 (G17) mAb (2MM)
MBS8576830-01mLAF405S 0.1mL(AF405S)
EUR 565

Mouse anti-Human gastrin-17 (G17) mAb (2MM)
MBS8576830-01mLAF610 0.1mL(AF610)
EUR 565

Mouse anti-Human gastrin-17 (G17) mAb (2MM)
MBS8576830-01mLAF635 0.1mL(AF635)
EUR 565

Rabbit Anti Gastrin Polyclonal Antibody
CPBT-65757RG 50 µl*
EUR 567
Description: Rabbit

Goat Gastrin I/gastrin-17 ELISA kit
E01A48510 96T
EUR 700
Description: ELISA

Goat Gastrin I/gastrin-17 ELISA kit
E06G0416-48wellsplate 48 wells plate
EUR 280

Goat Gastrin I/gastrin-17 ELISA kit
E06G0416-96wellsplate 96 wells plate
EUR 405

Human Gastrin I/gastrin-17 ELISA kit
E01A4842 96T
EUR 700
Description: ELISA

Mouse Gastrin I/gastrin-17 ELISA kit
E01A22341 96T
EUR 700
Description: ELISA

Sheep Gastrin I/gastrin-17 ELISA kit
E01A100803 96T
EUR 700
Description: ELISA

Sheep Gastrin I/gastrin-17 ELISA kit
E14G0416-48wellsplate 48 wells plate
EUR 280

Sheep Gastrin I/gastrin-17 ELISA kit
E14G0416-96wellsplate 96 wells plate
EUR 405

We show that the variants identified IKZF1 (p.His195Arg) alter histidine residues absolutely conserved required for folding of the three zinc-finger protein IKAROS, lead to the loss of the characteristics of nuclear immunofluorescence staining pattern. In our case, genetic testing is essential for diagnosis IKAROS haploinsufficiency, the presentation of which are known, including infections, aberrant hematopoiesis, leukemia, and age-related decline in humoral immunity. Our family studies underscore that, after infection, ITP is the most common clinical manifestation of both IKAROS haploinsufficiency.