Cells CD4 + T helper cells able to differentiate into several subsets effector perform diverse functions during the adaptive immune response. Each subset differentiation is regulated, largely, by environmental cytokine signaling and subsequent activation of downstream transcription factor network of cell-intrinsic.
Ikaros zinc finger (IkZF) transcription factor known regulator of the development of immune cells, including CD4 + T cell subset Over the past decade, members of the family IkZF also been involved in the differentiation and function of T helper cell subset of individuals, including the T helper 1 (THHHFH ) and regulatory (Treg) cells T. Now, an increasing body of literature suggests that cell-specific cytokine different environment which is responsible for the development of any part results in differential expression IkZF factor of the entire population of T helper.
Interestingly, recent studies have shown that members of IkZF affects T helper differentiation inside the feed-forward mode through the regulatory cytokine-signaling pathways are the same. Here, we review the increasingly important role for IkZF transcription factor in the differentiation of effector CD4 + T helper cell subsets.
Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation.
Assessing Relevance of Functional Variants in IKAROS Family Zinc Finger Protein 1 (IKZF1) in Cohort Patients With Primary Immunodeficiency.
common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency. Patients with CVID are susceptible to recurrent bacterial infections because of a failure of adequate immunoglobulin production. monogenetic defects have been identified in ~ 25% of patients with CVID.
More recently, mutations in IKZF1, encoding zinc-finger transcription factor IKAROS widely expressed in hematopoietic cells, has been associated with CVID like phenotype. Here we describe 11 patients with heterozygous variant IKZF1 of eight different families with autosomal dominant CVID and two siblings with a variant IKZF1 with inflammatory bowel disease (IBD). This study shows that the mutation affects the DNA binding domain IKAROS can disrupt the interaction with the target DNA sequence so as to prevent and localization pericentromeric heterochromatin (HC-PC) protein. Our results also indicate a decrease in localization pericentromeric of IKAROS by overexpression of truncated variants, due to mature stop codon in IKZF1.
We also describe additional variant in TNFSF10, encoding Tumor Necrosis Factor Related Apoptosis Encouraging ligand (TRAIL), also served in the individuals of A. Our Families results show that these variants can disrupt TRAIL-induced apoptosis in the target cell line and forbid the activation of NF by TRAIL and can act as a modifier in Family A We report a new variant in IKZF1 associated with IKAROS haploinsufficiency in patients with familial immune thrombocytopenia (ITP). IKAROS, encoded by the gene IKZF1, a zinc-finger transcription factor hematopoietic can directly bind to DNA.
Gastrin 17 (G-17) Antibody
MBS569519-1mg
MyBiosource
1mg
EUR 1080
Gastrin 17 (G-17) Antibody
MBS569519-5x1mg
MyBiosource
5x1mg
EUR 4660
anti- Gastrin antibody
FNab03355
FN Test
100µg
EUR 702
Description: Antibody raised against Gastrin
Anti Gastrin-17-C terminal mouse monoclonal antibody
MBS157959-01mL
MyBiosource
0.1mL
EUR 350
Anti Gastrin-17-C terminal mouse monoclonal antibody
MBS157959-5x01mL
MyBiosource
5x0.1mL
EUR 1250
Anti Gastrin-17-N terminal mouse monoclonal antibody
MBS157960-01mL
MyBiosource
0.1mL
EUR 350
Anti Gastrin-17-N terminal mouse monoclonal antibody
MBS157960-5x01mL
MyBiosource
5x0.1mL
EUR 1250
Anti- Gastrin/ CCK Antibody
GWB-8D712D
GenWay Biotech
0.05 ml
Ask for price
Gastrin 17 Antigen (HM682)
VAng-Cr3882-1mg
Creative Biolabs
1 mg
EUR 2023.2
Description: Gastrin 17 Antigen, Host/Source: Synthetic. Matched Pair: HM682 (detection).
Gastrin 17 Antigen (HM683)
VAng-Cr3884-1mg
Creative Biolabs
1 mg
EUR 2023.2
Description: Gastrin 17 Antigen, Host/Source: Synthetic. Matched Pair: HM683 (detection).
Gastrin Antibody
8C0205
AAT Bioquest
50ug
EUR 368
Description: Gastrin Antibody
Gastrin Antibody
33384-100ul
SAB
100ul
EUR 302.4
Gastrin Antibody
33384-50ul
SAB
50ul
EUR 224.4
Gastrin antibody
70R-49765
Fitzgerald
100 ul
EUR 242
Description: Purified Polyclonal Gastrin antibody
Gastrin antibody
70R-31204
Fitzgerald
100 ug
EUR 294
Description: Rabbit polyclonal Gastrin antibody
Gastrin antibody
20R-2560
Fitzgerald
50 uL
EUR 489
Description: Guinea Pig polyclonal Gastrin antibody
Gastrin antibody
20R-GR002
Fitzgerald
250 uL
EUR 454
Description: Rabbit polyclonal Gastrin antibody
Gastrin antibody
20-GR03
Fitzgerald
1 ml
EUR 225
Description: Rabbit polyclonal Gastrin antibody
Gastrin Antibody
AF5352-100ul
Affinity Biosciences
100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)
Gastrin Antibody
AF5352-200ul
Affinity Biosciences
200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)
Gastrin Antibody
AF0593-100ul
Affinity Biosciences
100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)
Gastrin Antibody
AF0593-200ul
Affinity Biosciences
200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)
Gastrin Antibody
C0205-100ul
Assay Biotech
100μl
EUR 217
Description: Gastrin Rabbit Polyclonal Antibody
Gastrin Antibody
C0205-50ul
Assay Biotech
50μl
EUR 143.5
Description: Gastrin Rabbit Polyclonal Antibody
Gastrin Antibody
E11-0205C
EnoGene
100μg/100μl
EUR 225
Description: Available in various conjugation types.
Gastrin Antibody
E18-5352-1
EnoGene
50μg/50μl
EUR 145
Description: Available in various conjugation types.
Gastrin Antibody
E18-5352-2
EnoGene
100μg/100μl
EUR 225
Description: Available in various conjugation types.
Gastrin Antibody
E033384
EnoGene
100μg/100μl
EUR 255
Description: Available in various conjugation types.
Gastrin Antibody
E18-0593-1
EnoGene
50μg/50μl
EUR 145
Description: Available in various conjugation types.
Gastrin Antibody
E18-0593-2
EnoGene
100μg/100μl
EUR 225
Description: Available in various conjugation types.
Gastrin Antibody
E38PA9623
EnoGene
100ul
EUR 225
Description: Available in various conjugation types.
Gastrin Antibody
E38PA9685
EnoGene
100ul
EUR 225
Description: Available in various conjugation types.
Gastrin Antibody
MBS5314385-01mL
MyBiosource
0.1mL
EUR 470
Gastrin Antibody
MBS5314385-5x01mL
MyBiosource
5x0.1mL
EUR 1955
Gastrin antibody
MBS535166-5x1mL
MyBiosource
5x1mL
EUR 1350
Gastrin antibody
MBS536321-025mL
MyBiosource
0.25mL
EUR 730
Gastrin antibody
MBS536321-5x025mL
MyBiosource
5x0.25mL
EUR 3135
Gastrin Antibody
MBS8584424-01mL
MyBiosource
0.1mL
EUR 305
Gastrin Antibody
MBS8584424-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 465
Gastrin Antibody
MBS8584424-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 465
Gastrin Antibody
MBS8584424-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 465
Gastrin Antibody
MBS8584424-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 465
Gastrin Antibody
MBS8584486-01mL
MyBiosource
0.1mL
EUR 305
Gastrin Antibody
MBS8584486-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 465
Gastrin Antibody
MBS8584486-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 465
Gastrin Antibody
MBS8584486-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 465
Gastrin Antibody
MBS8584486-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 465
Gastrin Antibody
MBS9601524-01mL
MyBiosource
0.1mL
EUR 260
Gastrin Antibody
MBS9601524-02mL
MyBiosource
0.2mL
EUR 305
Gastrin Antibody
MBS9601524-5x02mL
MyBiosource
5x0.2mL
EUR 1220
Gastrin Antibody
MBS9600443-01mL
MyBiosource
0.1mL
EUR 260
Gastrin Antibody
MBS9600443-02mL
MyBiosource
0.2mL
EUR 305
Gastrin Antibody
MBS9600443-5x02mL
MyBiosource
5x0.2mL
EUR 1220
Gastrin Antibody
MBS9232637-01mL
MyBiosource
0.1mL
EUR 415
Gastrin Antibody
MBS9232637-5x01mL
MyBiosource
5x0.1mL
EUR 1841
Gastrin Antibody
MBS8511000-005mg
MyBiosource
0.05mg
EUR 235
Gastrin Antibody
MBS8511000-01mg
MyBiosource
0.1mg
EUR 305
Gastrin Antibody
MBS8511000-01mLAF405M
MyBiosource
0.1mL(AF405M)
EUR 465
Gastrin Antibody
MBS8511000-01mLAF546
MyBiosource
0.1mL(AF546)
EUR 465
Gastrin Antibody
MBS8511000-01mLAF750
MyBiosource
0.1mL(AF750)
EUR 465
Gastrin antibody
MBS833321-005mL
MyBiosource
0.05mL
EUR 785
Gastrin antibody
MBS833321-5x05mL
MyBiosource
5x0.5mL
EUR 3370
Gastrin Antibody
MBS854021-01mg
MyBiosource
0.1mg
EUR 305
Gastrin Antibody
MBS854021-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 465
Gastrin Antibody
MBS854021-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 465
Gastrin Antibody
MBS854021-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 465
Gastrin Antibody
MBS854021-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 465
Gastrin Antibody
MBS8511983-005mg
MyBiosource
0.05mg
EUR 235
Gastrin Antibody
MBS8511983-01mg
MyBiosource
0.1mg
EUR 305
Gastrin Antibody
MBS8511983-01mLAF405M
MyBiosource
0.1mL(AF405M)
EUR 465
Gastrin Antibody
MBS8511983-01mLAF546
MyBiosource
0.1mL(AF546)
EUR 465
Gastrin Antibody
MBS8511983-01mLAF750
MyBiosource
0.1mL(AF750)
EUR 465
Gastrin Antibody
MBS9402805-005mL
MyBiosource
0.05mL
EUR 245
Gastrin Antibody
MBS9402805-01mL
MyBiosource
0.1mL
EUR 305
Gastrin Antibody
MBS9402805-5x01mL
MyBiosource
5x0.1mL
EUR 1230
Gastrin Antibody
MBS9504608-005mL
MyBiosource
0.05mL
EUR 285
Gastrin Antibody
MBS9504608-01mL
MyBiosource
0.1mL
EUR 385
Gastrin Antibody
MBS9504608-5x01mL
MyBiosource
5x0.1mL
EUR 1590
Biotin - Gastrin (1-17)
5-00788
CHI Scientific
4 x 1mg
EUR 171.99
Description: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
Gastrin 17 (G-17) Antigen >95%
MBS569567-1mg
MyBiosource
1mg
EUR 935
Gastrin 17 (G-17) Antigen >95%
MBS569567-5x1mg
MyBiosource
5x1mg
EUR 4005
Gastrin 17 (G-17) Antigen >95%
MBS569568-1mg
MyBiosource
1mg
EUR 935
Gastrin 17 (G-17) Antigen >95%
MBS569568-5x1mg
MyBiosource
5x1mg
EUR 4005
Gastrin 17 (G-17) Antigen >95%
MBS569836-1mg
MyBiosource
1mg
EUR 935
Gastrin 17 (G-17) Antigen >95%
MBS569836-5x1mg
MyBiosource
5x1mg
EUR 4005
Gastrin (GT) Antibody
abx131060-100l
Abbexa
100 µl
EUR 812.5
Gastrin (GT) Antibody
20-abx131060
Abbexa
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10 ug
50 ug
100 ug
200 ug
1 mg
Gastrin (GT) Antibody
abx131060-20l
Abbexa
20 µl
EUR 287.5
Gastrin (GT) Antibody
abx131060-50l
Abbexa
50 µl
EUR 362.5
Gastrin (GT) Antibody
20-abx176568
Abbexa
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10 ug
50 ug
100 ug
200 ug
1 mg
Gastrin (GT) Antibody
abx176568-1096tests
Abbexa
10 × 96 tests
EUR 712.5
Gastrin (GT) Antibody
abx176568-596tests
Abbexa
5 × 96 tests
EUR 325
Gastrin (GT) Antibody
abx176568-96tests
Abbexa
96 tests
EUR 262.5
Gastrin (GT) Antibody
20-abx176569
Abbexa
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10 ug
50 ug
100 ug
200 ug
1 mg
Gastrin (GT) Antibody
abx176569-1096tests
Abbexa
10 × 96 tests
EUR 712.5
Gastrin (GT) Antibody
abx176569-596tests
Abbexa
5 × 96 tests
EUR 325
Gastrin (GT) Antibody
abx176569-96tests
Abbexa
96 tests
EUR 262.5
Gastrin (GT) Antibody
20-abx176570
Abbexa
Ask for price
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Gastrin (GT) Antibody
20-abx176571
Abbexa
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Gastrin (GT) Antibody
20-abx172525
Abbexa
Ask for price
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Gastrin (GT) Antibody
abx172525-1ml
Abbexa
1 ml
EUR 750
Gastrin (GT) Antibody
20-abx172526
Abbexa
Ask for price
Ask for price
Gastrin (GT) Antibody
abx172526-1ml
Abbexa
1 ml
EUR 812.5
Gastrin (GT) Antibody
20-abx172527
Abbexa
Ask for price
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Gastrin (GT) Antibody
abx172527-1ml
Abbexa
1 ml
EUR 850
Gastrin (GT) Antibody
20-abx172528
Abbexa
Ask for price
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Gastrin (GT) Antibody
abx100041-100l
Abbexa
100 µl
EUR 275
Gastrin (GT) Antibody
20-abx100041
Abbexa
Ask for price
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10 ug
50 ug
100 ug
200 ug
1 mg
Gastrin (GT) Antibody
abx100041-1ml
Abbexa
1 ml
EUR 775
Gastrin (GT) Antibody
abx100041-200l
Abbexa
200 µl
EUR 350
Gastrin (GT) Antibody
abx100042-100l
Abbexa
100 µl
EUR 262.5
Gastrin (GT) Antibody
20-abx100042
Abbexa
Ask for price
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10 ug
50 ug
100 ug
200 ug
1 mg
Gastrin (GT) Antibody
abx100042-1ml
Abbexa
1 ml
EUR 712.5
Gastrin (GT) Antibody
abx100042-200l
Abbexa
200 µl
EUR 325
Gastrin (GT) Antibody
abx100043-100l
Abbexa
100 µl
EUR 262.5
Gastrin (GT) Antibody
20-abx100043
Abbexa
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10 ug
50 ug
100 ug
200 ug
1 mg
Gastrin (GT) Antibody
abx100043-1ml
Abbexa
1 ml
EUR 725
Gastrin (GT) Antibody
abx100043-200l
Abbexa
200 µl
EUR 337.5
Human Gastrin Antibody
10901-05011
AssayPro
150 ug
EUR 175
Rat Gastrin I/gastrin-17 ELISA kit
E01A13601
BlueGene
96T
EUR 700
Description: ELISA
Rat Gastrin I/gastrin-17 ELISA kit
E02G0416-48wellsplate
BlueGene
48 wells plate
EUR 280
Rat Gastrin I/gastrin-17 ELISA kit
E02G0416-96wellsplate
BlueGene
96 wells plate
EUR 405
human anti-human gastrin-17(G17) mAb(1XH)
E409C25-hA100
EnoGene
100μL
EUR 395
Description: Available in various conjugation types.
human anti-human gastrin-17(G17) mAb(2MH)
E409C25-hB100
EnoGene
100μL
EUR 395
Description: Available in various conjugation types.
mouse anti-human gastrin-17(G17) mAb(1XM)
E409C25-mA100
EnoGene
100μL
EUR 395
Description: Available in various conjugation types.
mouse anti-human gastrin-17(G17) mAb(2MM)
E409C25-mB100
EnoGene
100μL
EUR 395
Description: Available in various conjugation types.
human anti-human gastrin-17(G17) mAb(1XH)
E4A09H06-hA
EnoGene
50ug
EUR 255
Description: Available in various conjugation types.
human anti-human gastrin-17(G17) mAb(2MH)
E4A09H06-hB
EnoGene
50ug
EUR 255
Description: Available in various conjugation types.
Human anti-Human gastrin-17 (G17) mAb (1XH)
MBS8576827-005mg
MyBiosource
0.05mg
EUR 325
Human anti-Human gastrin-17 (G17) mAb (1XH)
MBS8576827-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 565
Human anti-Human gastrin-17 (G17) mAb (1XH)
MBS8576827-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 565
Human anti-Human gastrin-17 (G17) mAb (1XH)
MBS8576827-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 565
Human anti-Human gastrin-17 (G17) mAb (1XH)
MBS8576827-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 565
Human anti-Human gastrin-17 (G17) mAb (2MH)
MBS8576828-005mg
MyBiosource
0.05mg
EUR 325
Human anti-Human gastrin-17 (G17) mAb (2MH)
MBS8576828-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 565
Human anti-Human gastrin-17 (G17) mAb (2MH)
MBS8576828-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 565
Human anti-Human gastrin-17 (G17) mAb (2MH)
MBS8576828-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 565
Human anti-Human gastrin-17 (G17) mAb (2MH)
MBS8576828-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 565
Mouse anti-Human gastrin-17 (G17) mAb (1XM)
MBS8576829-005mg
MyBiosource
0.05mg
EUR 325
Mouse anti-Human gastrin-17 (G17) mAb (1XM)
MBS8576829-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 565
Mouse anti-Human gastrin-17 (G17) mAb (1XM)
MBS8576829-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 565
Mouse anti-Human gastrin-17 (G17) mAb (1XM)
MBS8576829-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 565
Mouse anti-Human gastrin-17 (G17) mAb (1XM)
MBS8576829-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 565
Mouse anti-Human gastrin-17 (G17) mAb (2MM)
MBS8576830-005mg
MyBiosource
0.05mg
EUR 325
Mouse anti-Human gastrin-17 (G17) mAb (2MM)
MBS8576830-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 565
Mouse anti-Human gastrin-17 (G17) mAb (2MM)
MBS8576830-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 565
Mouse anti-Human gastrin-17 (G17) mAb (2MM)
MBS8576830-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 565
Mouse anti-Human gastrin-17 (G17) mAb (2MM)
MBS8576830-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 565
Rabbit Anti Gastrin Polyclonal Antibody
CPBT-65757RG
Creative Diagnostics
50 µl*
EUR 567
Description: Rabbit
Goat Gastrin I/gastrin-17 ELISA kit
E01A48510
BlueGene
96T
EUR 700
Description: ELISA
Goat Gastrin I/gastrin-17 ELISA kit
E06G0416-48wellsplate
BlueGene
48 wells plate
EUR 280
Goat Gastrin I/gastrin-17 ELISA kit
E06G0416-96wellsplate
BlueGene
96 wells plate
EUR 405
Human Gastrin I/gastrin-17 ELISA kit
E01A4842
BlueGene
96T
EUR 700
Description: ELISA
Mouse Gastrin I/gastrin-17 ELISA kit
E01A22341
BlueGene
96T
EUR 700
Description: ELISA
Sheep Gastrin I/gastrin-17 ELISA kit
E01A100803
BlueGene
96T
EUR 700
Description: ELISA
Sheep Gastrin I/gastrin-17 ELISA kit
E14G0416-48wellsplate
BlueGene
48 wells plate
EUR 280
Sheep Gastrin I/gastrin-17 ELISA kit
E14G0416-96wellsplate
BlueGene
96 wells plate
EUR 405
We show that the variants identified IKZF1 (p.His195Arg) alter histidine residues absolutely conserved required for folding of the three zinc-finger protein IKAROS, lead to the loss of the characteristics of nuclear immunofluorescence staining pattern. In our case, genetic testing is essential for diagnosis IKAROS haploinsufficiency, the presentation of which are known, including infections, aberrant hematopoiesis, leukemia, and age-related decline in humoral immunity. Our family studies underscore that, after infection, ITP is the most common clinical manifestation of both IKAROS haploinsufficiency.