Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits, Uncategorized, Vector & Virus, Western Blot

Development of Label-Free Impedimetric Immunosensors for IKZF1 and IKZF3 Femtomolar Detection for Monitoring Multiple Myeloma Patients Treated with Lenalidomide

Circulating epigenetic biomarkers for detection of recurrent colorectal cancer.
Posted by Seth

Lenalidomide is an immunomodulatory drug (IMiD) is used to treat multiple myeloma (MM) patients. Lenalidomide destroy MM cells to induce ubiquitination and degradation as a result of the Ikaros family zinc finger protein 1 and 3 (IKZF1 and IKZF3). IKZF1 and IKZF3 high expression in MM less sensitivity results for lenalidomide treatment and possible cytotoxic effect. Therefore, detecting IKZF1 and IKZF3 protein expression is very important in the treatment of MM.

Here, we report the manufacture of new electrochemical immunosensor free label for the rapid detection and quantification of IKZF1 and IKZF3 using electrochemical impedance spectroscopy (EIS). gold electrodes are used to fabricate immunosensors by paralyzing IKZF1 and IKZF3 specific antibodies using cysteamine and crosslinkers PDITC. The immunosensors able to detect the protein level IKZF1 and IKZF3 with a lower detection limit respectively 0.68 and 0.97 pg / ml (11.8 and 16.7 FM).

In addition, the successful application immunosensors’ in human serum and their high selectivity and sensitivity allows the application they may be in other biofluids as point-of-care simple tool for monitoring multiple myeloma patients treated with lenalidomide, to prevent drug cytotoxicity and minimize side effects .Ikaros zinc finger 1 (IKZF1 or Ikaros) is a DNA-binding zinc finger transcription factor that acts as a regulator of hematopoietic critical lymphocytes and myeloid differentiation. Loss-of-function germline heterozygous mutation in the DNA-binding IKZF1 affecting described as the cause of two different primary immunodeficiency (PID) / error congenital immune disease.

Acting with haploinsufficiency mutations present with common variable immune deficiency like phenotype mainly characterized by increased susceptibility to infection. Mutations present mode dominant negative act with immunodeficiency phenotype combined with the high prevalence of pneumonia jirovecii pneumonia. IKAROS disease pathophysiology and related manifestations in patients with PID are reviewed here.

Development of Label-Free Impedimetric Immunosensors for IKZF1 and IKZF3 Femtomolar Detection for Monitoring Multiple Myeloma Patients Treated with Lenalidomide
Development of Label-Free Impedimetric Immunosensors for IKZF1 and IKZF3 Femtomolar Detection for Monitoring Multiple Myeloma Patients Treated with Lenalidomide

[Ikaros Family Zinc Finger 1 Mutations Are a Factor poor prognosis for Adult Patients with B-Cell Acute Lymphoblastic Leukemia].

To investigate the prognosis of patients with acute lymphoblastic leukemia-mature B cells (B-ALL), accompanied by family Ikaros zinc finger 1 (IKZF1) mutation, and to explore the role of stem cell transplantation of hematopoietic allogeneic (allo-HSCT) in improving the clinical outcomes of clinical data patients.The of 164 adult patients with B-ALL who received IKZF-1 mutation by capillary electrophoresis detection of bone marrow collected, and the relationship between IKZF-1 gene mutation and prognosis of adult patients with B-ALL were analyzed.


RESULTS
Among 164 adult B-ALL patients, patients with IKZF-1 mutation (IKZF-1 +) was 80 cases, while patients without IKZF-1 mutation (IKZF-1) was 84 cases. Among the 80 IKZF-1 positive, according to the methods of treatment of patients after complete remission is divided into HSCT group (48 cases) and chemotherapy group (32 cases). Analysis showed that the 3-year overall survival (OS) and leukemia-free survival (LFS) level in the group lower.

BGB-102

HY-15732 10mg
EUR 6041

EL-102

HY-16187 10mM/1mL
EUR 376

LSZ-102

HY-111486 50mg
EUR 3321

MM-102

HY-12220 10mg
EUR 298

IAXO-102

HY-125171 50mg
EUR 1944

PPQ-102

B3504-10 10 mg
EUR 242

PPQ-102

B3504-5 5 mg
EUR 151

PPQ-102

B3504-50 50 mg
EUR 863

PM 102

B5517-1 1 mg
EUR 601

MM-102

B1582-2 2 mg
EUR 128
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B1582-20 20 mg
EUR 593
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B2364-25
EUR 588

MM-102

B2364-5
EUR 185

p38 protein

E20-80078 20ug
EUR 408

p38 protein

E20-80079 20ug
EUR 408

p38 Antibody

35478-100ul 100ul
EUR 390

p38 Antibody

20-abx133223
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

20-abx141038
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

20-abx007541
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

abx236076-100ug 100 ug
EUR 481

p38 Antibody

48644-100ul 100ul
EUR 333

p38 Antibody

48644-50ul 50ul
EUR 239

anti-p38

YF-PA11120 50 ug
EUR 363
Description: Mouse polyclonal to p38

anti-p38

YF-PA11121 100 ug
EUR 403
Description: Rabbit polyclonal to p38

anti-p38

YF-PA23519 50 ul
EUR 334
Description: Mouse polyclonal to p38

anti-p38

YF-PA23520 50 ul
EUR 334
Description: Mouse polyclonal to p38

anti-p38

YF-PA23521 50 ul
EUR 334
Description: Mouse polyclonal to p38

p38 antibody

70R-51505 100 ul
EUR 268
Description: Purified Polyclonal p38 antibody

p38 antibody

70R-51506 100 ul
EUR 287
Description: Purified Polyclonal p38 antibody

MM-102 (TFA)

HY-12220A 10mM/1mL
EUR 263

BP-1-102

HY-100493 100mg
EUR 1345

LB (Lennox)

102 500 g
EUR 101

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor

E1B1863 1mg
EUR 161

p38 Polyclonal Antibody

ES8347-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 Polyclonal Antibody

ES8347-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 Polyclonal Antibody

ES4837-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4838-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES4838-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES4837-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES3111-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES3112-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES3112-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES3111-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 alpha-MAPK14

RA15053 100 ug
EUR 526

Anti-p38 Antibody

A00176 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for p38 Antibody (MAPK14) detection.tested for WB in Human, Mouse, Rat.

p38 Polyclonal Antibody

ABP57354-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP57354-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP57354-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP52112-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52113-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP53838-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53839-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Blocking Peptide

20-abx061736
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg

p38 Blocking Peptide

20-abx062080
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

p38 (pY323) Antibody

20-abx133058
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 (pY182) Antibody

20-abx134951
  • EUR 384.00
  • EUR 606.00
  • EUR 230.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 (pT180) Antibody

20-abx009863
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 MAPK Antibody

20-abx012798
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

p38 MAPK Antibody

20-abx012875
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

p38 MAPK Antibody

abx236077-100ug 100 ug
EUR 481

p38 Blocking Peptide

20-abx161932
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Anti-p38 antibody

STJ97615 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94876 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94877 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94878 200 µl
EUR 197
Description: p38 is a protein encoded by the MAPK14 gene which is approximately 41,2 kDa. p38 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the IL-2 pathway, toll-like receptor signalling pathways, the VEGF signalling pathway and 4-1BB pathway. This protein falls under the MAP kinase family. It acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. p38 is expressed in the brain, heart, placenta, pancreas and skeletal muscle. Mutations in the MAPK14 gene may result in patellar tendinitis and lumbosacral lipoma. STJ94878 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p38 protein.

Anti-p38 antibody

STJ94879 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-P38 antibody

STJ98898 200 µl
EUR 197
Description: Mouse monoclonal to P38.

Anti-P38 antibody

STJ98899 200 µl
EUR 197
Description: Mouse monoclonal to P38.

p38 Polyclonal Antibody

41305-100ul 100ul
EUR 252

p38 Polyclonal Antibody

41305-50ul 50ul
EUR 187

p38 Polyclonal Antibody

41306-100ul 100ul
EUR 252

p38 Polyclonal Antibody

41306-50ul 50ul
EUR 187

p38 MAPK Antibody

49379-100ul 100ul
EUR 333

p38 MAPK Antibody

49379-50ul 50ul
EUR 239

anti- p38 antibody

FNab06076 100µg
EUR 505.25
Description: Antibody raised against p38

p38 MAPK Antibody

AF6455 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody

AF6456 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody

AF6457 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

Anti-p38 alpha

DB1039 100 tests
EUR 474

Anti-p38 beta

DB1040 100 tests
EUR 474

Anti-p38 gamma

DB1041 100 tests
EUR 474

Anti-p38 delta

DB1042 100 tests
EUR 474

Anti-p38 alpha

DB-1039 100 tests
EUR 474

Anti-p38 beta

DB-1040 100 tests
EUR 474

Anti-p38 gamma

DB-1041 100 tests
EUR 474

Anti-p38 delta

DB-1042 100 tests
EUR 474

Anti-p38-a

DB-161-0.05 50 μl
EUR 269

Anti-p38-a

DB-161-0.1 100 μl
EUR 422

Anti-p38-b

DB-162-0.05 50 μl
EUR 269

Anti-p38-b

DB-162-0.1 100 μl
EUR 422

IKZF1 + remote OS and LFS level in the transplant group was 50.3% ± 8.3%, 41.6% ± 8.5%; OS and LFS fare in the chemotherapy group was 33.7% ± 12.8%, 31.5% ± 9.5%, which is lower than in the group IKZF1- (transplantation group: 79.5% ± 7.6%, 64.0% ± 8.4%, while the chemotherapy group, 54.4% ± 9.9%, 40.6% ± 9.6% respectirely (P <0.05) among the 80 patients with B-ALL with IKZF- 1- mutations, 3-year OS and LFS levels were significantly higher in the transplant group (55.3% ± 7.5%, 48.3% ± 7.6%) compared with chemotherapy group (32.9% ± 11 8%, 28.4% ± 10.3%) with IKZF1 mutations (P <0.05).

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